NDLI: 10C-5 Identification of Hepatocellular Carcinomas with Contrast Enhanced 40 MHz Ultrasound in Hepatitis B Virus X Protein Transgenic Mice

Content Provider	IEEE Xplore Digital Library
Author	Ai-Ho Liao Ya-Chien Cheng Shiou-Hwei Yeh Pai-Chi Li
Copyright Year	2007
Description	Author affiliation: Nat. Taiwan Univ., Taipei (Ai-Ho Liao; Ya-Chien Cheng)
Abstract	Contrast-enhanced ultrasound (CEUS) imaging is a reliable noninvasive clinical method of detecting and characterizing hepatocellular carcinoma (HCC) lesions. In this study, high-frequency (40 MHz) CEUS imaging was applied to small animals. Specifically, high-frequency ultrasound liver imaging with albumin-shelled microbubbles was employed to characterize suspected HCC lesions that developed in five Hepatitis B virus X (HBx) transgenic mice at around 14 to 16 months of age. After injecting the contrast agent, the time-intensity curves (TICs) of suspected HCC lesions, vessels in suspected HCC lesions, and surrounding liver parenchyma tissues were measured for 30 minutes. In four of the five mice, the intensity of the TICs of the suspected HCC lesions was enhanced by a mean of 13.5 dB in the arterial phase (at around 10-30 seconds), with a rapid "washout" starting at the beginning of the portal phase. The peak intensity relative to the baseline also increased from 3.27 dB at 18 months to 23.74 dB at 22 months. On the other hand, the mean contrast between the suspected HCC lesion and the liver parenchyma increased by 6.6 dB, thus allowing clear detection of the HCC margin. Histopathology investigations confirmed the HCC development in these four mice. For the remaining mouse, the absence of the peak in the arterial phase was also consistent with the histopathology finding of dysplasia. These results demonstrated that high-frequency CEUS imaging is an effective preclinical tool for identifying HCC lesions in mice.
Starting Page	896
Ending Page	899
File Size	821775
Page Count	4
File Format	PDF
ISBN	9781424413836
ISSN	10510117
DOI	10.1109/ULTSYM.2007.229
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-28
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Liver diseases Proteins Mice Lesions Portals Biomedical imaging Animals Blood High-resolution imaging
Content Type	Text
Resource Type	Article

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