NDLI: Numerical study of a novel passive micromixer design

Content Provider	IEEE Xplore Digital Library
Author	Bhopte, S. Sammakia, B. Murray, B.
Copyright Year	2010
Description	Author affiliation: Mechanical Engineering Department, State University of New York at Binghamton, IEEC, P.O. Box 6000, Vestal Parkway East, 13902-6000, USA (Bhopte, S.; Sammakia, B.; Murray, B.)
Abstract	Miniaturization is the trend in analytical chemistry and life sciences. In the past two decades, miniaturization of fluid handling and fluid analysis has been emerging in the interdisciplinary research field of microfluidics. Some of the microfluidic applications are drug delivery, lab-on-a-chip, pharmaceutical development, synthesis of amino acids etc. Most of these applications are used for biochemistry analysis and require rapid mixing in minute quantities. Microchannel flows, due to very low flow rate, are characterized by very low Reynolds number (Re≪100). Owing to laminar flow conditions it is difficult to achieve effective mixing of two fluids as is the case for turbulent flow. If the mixing is obtained primarily by a diffusion mechanism then fast mixing becomes impossible because biological reagents usually have very low diffusivity on the order of $10^{−10}$ $m^{2}/s.$ Hence microfluidic mixing is a very challenging problem because it requires fast and efficient mixing of low diffusivity fluids under laminar flow conditions [1–3]. In this paper, problem of microfluidic mixing is studied numerically using the CFD code FLUENT™[4–11]. To present the study, mixing of two low diffusivity fluids (D = $10^{−10}$ $m^{2}/s)$ is numerically investigated in ⊢ microchannel. Due to laminar flow conditions very poor mixing is observed in ⊢ microchannel. Previously established geometric modification called “two-way split flow technique” is applied to the baseline case. This technique involves splitting of both the inlets of the ⊢ microchannel in half such that the net flow rate at the outlet remains the same. Application of this technique is shown to improve mixing by ∼250% when it is compared to ⊢ microchannel. Based on two-way split flow design technique, novel split-and-merge (SAM) mixer designs are proposed. All the SAM mixer designs proposed show an improvement in mixing between 300 – 500% when compared with ⊢ microchannel, for same flow conditions and residence times. Pressure drops of proposed SAM mixer designs are less than 50% higher than ⊢ microchannel. Hence all the micromixer designs based on two-way split flow techniques are shown to be efficient and low pressure drop mixers.
Starting Page	1
Ending Page	10
File Size	600295
Page Count	10
File Format	PDF
ISBN	9781424453429
ISSN	10879870
e-ISBN	9781424453436
DOI	10.1109/ITHERM.2010.5501318
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-02
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microchannel Microfluidics Chemistry Drug delivery Lab-on-a-chip Pharmaceuticals Amino acids Biochemistry Biochemical analysis Biological information theory
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in