NDLI: Magnetic Nanoparticles to Enhance Cell Seeding and Distribution in Tissue Engineering Scaffolds

Content Provider	IEEE Xplore Digital Library
Author	Thevenot, P. Sohaebuddin, S. Poudyal, N. Liu, J.P. Liping Tang
Copyright Year	2008
Description	Author affiliation: Dept. of Phys., Univ. of Texas at Arlington, Arlington, TX (Thevenot, P.; Sohaebuddin, S.)
Abstract	The success of tissue engineering scaffolds is intimately linked with the ability of the seeded cells to adequately distribute and proliferate within the scaffold matrix. In tissue engineering scaffolds, it is difficult to achieve adequate distribution due to the hydrophobic nature of most scaffold materials and poor initial distribution following scaffold seeding. In this study, we investigated the distribution of cells in PLGA salt-leached scaffolds after seeding with magnetic nanoparticle loaded cells with a neodymium magnet placed below. The combined use of magnetic nanoparticle seeded cells and magnetic force was able to not only increase the total number of scaffold adherent cells, but also increase the infiltration and distribution compared with controls. This method to control the distribution of cells may provide a method to increase the functionality of tissue engineering scaffolds.
Starting Page	646
Ending Page	649
File Size	728218
Page Count	4
File Format	PDF
ISBN	9781424421039
DOI	10.1109/NANO.2008.196
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-08-18
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computer architecture Microprocessors Magnetic resonance imaging Nanoparticles Tissue engineering Perpendicular magnetic anisotropy Magnetic anisotropy
Content Type	Text
Resource Type	Article

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