NDLI: Realistic visual and haptic feedback simulator for real-time cell indentation

Content Provider	IEEE Xplore Digital Library
Author	Ladjal, H. Hanus, J.-L. Pillarisetti, A. Keefer, C. Ferreira, A. Desai, J.P.
Copyright Year	2010
Description	Author affiliation: Department of Animal and Avian Sciences, University of Maryland, College Park, USA (Keefer, C.) \|\| Institut PRISME, ENSI of Bourges 88, Boulevard Lahitolle, France (Ladjal, H.; Hanus, J.-L.; Ferreira, A.) \|\| Department of Mechanical Engineering, University of Maryland, College Park, USA (Pillarisetti, A.; Desai, J.P.)
Abstract	Comprehensive and training simulators that provide realistic visual and haptic feedback during cell indentation tasks are currently investigated. Complex cell geometry inherent to biological cells and intricate mechanical properties drive the need for precise mechanical and numerical modeling to assure accurate cell deformation and force calculations. Advances in alternative finite element formulation, such as mass-tensor approach, have reached the state where they are applicable to model soft cell deformation in real time. The geometrical characteristics and the mechanical properties for different cells are determined with AFM indentation. A real-time, haptics-enabled simulator for cell centered indentation has been developed which utilizes the atomic force microscopy data (mechanical and geometrical properties of embryonic stem cells (mESC)) to accurately replicate the indentation task and predict the cell deformation during indentation in real-time. This tool can be used as a mechanical marker to characterize the biological state of the cell. The operator is able to feel in real-time the change in the stiffness during cell deformation between fixed and live cells. A comparison study with finite element simulations using a commercial software and the experimental data demonstrate the effectiveness of the proposed physically-based model.
Starting Page	3993
Ending Page	3998
File Size	1317467
Page Count	6
File Format	PDF
ISBN	9781424466740
ISSN	21530866
e-ISBN	9781424466764
DOI	10.1109/IROS.2010.5653281
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-18
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Force Real time systems Solid modeling Data models Haptic interfaces Computer architecture Computational modeling
Content Type	Text
Resource Type	Article

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