NDLI: Detecting discriminative functional MRI activation patterns using space filling curves

Content Provider	IEEE Xplore Digital Library
Author	Kontos, D. Megalooikonomou, V. Ghubade, N. Faloutsos, C.
Copyright Year	2003
Description	Author affiliation: Dept. of Comput. & Information Sci., Temple Univ., Philadelphia, PA, USA (Kontos, D.; Megalooikonomou, V.; Ghubade, N.)
Abstract	We propose a novel approach for detecting discriminative patterns of functional MRI (fMRI) activation that are associated with non-spatial clinical variables (e.g. disease). The main idea is to map the 3D volumes to 1D following the traversal of the Hilbert space-filling curve, which has been shown to exhibit optimality in preserving the locality of the voxels after the domain transformation. We apply statistical tests of significance on groups of points, i.e., segments of the transformed domain, to detect discriminative patterns. To discover discriminative areas, we project these patterns to the initial 3D space by following the inverse mapping of the transformation. As a case study, we analyze an fMRI data set obtained from a study that explores neuroanatomical correlates of semantic processing in Alzheimer's disease. We seek to discover activation regions that discriminate controls from patients. We evaluate the results by presenting classification experiments that utilize information extracted from these regions. The discovered areas identified through back-projection are within the medial temporal lobe being consistent with prior findings. The overall classification accuracy ranged from 81% up to 100% for certain experimental settings. The proposed approach has great potential for elucidating structure-function relationships and can be valuable to human brain mapping.
Sponsorship	Whitaker Found
Starting Page	963
Ending Page	966
File Size	582495
Page Count	4
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279927
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Magnetic resonance imaging Filling Hilbert space Testing Data analysis Alzheimer's disease Data mining Temporal lobe Humans Brain mapping
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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