NDLI: Vasorelaxant effect of total flavones from Dendranthema morifolium on rat thoracic aorta

Content Provider	IEEE Xplore Digital Library
Author	Jin, H.-F. Shan, Q.-X. Jiang, H.-D. Tu, J. Bruce, I.C. Xia, Q.
Copyright Year	2003
Description	Author affiliation: Sch. of Med., Hong Kong Univ., China (Jin, H.-F.; Shan, Q.-X.)
Abstract	To investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel. cv. Hangju (FDM), tension was recorded from rat thoracic aortic rings. FDM completely relaxed, in a dose-dependent manner, the contractions induced by either phenylephrine (PE) or a high concentration of KCl (60 mM) in rings with intact endothelium. Mechanical removal of the endothelium did not significantly modify the vasorelaxant effect of FDM. In endothelium-denuded aortic rings depolarized by 60 mM KCl, FDM inhibited Ca/sup 2+/-induced contraction. FDM also reduced the transient contraction elicited by PE in Ca/sup 2+/-free medium, but had no effect on active phorbol ester-induced contraction. Pretreatment of endothelium-denuded aorta with propranolol, a beta-adrenoceptor antagonist, significantly attenuated the relaxant effect of FDM. These results indicate that FDM induces an endothelium-independent relaxation in rat aortic rings. The mechanisms may include the activation of beta-adrenergic receptors, reduction in Ca/sup 2+/ influx through the voltage-dependent and receptor-operated channels, and inhibition of intracellular Ca release in vascular smooth muscle cells.
Sponsorship	Whitaker Found
Starting Page	305
Ending Page	307
File Size	310513
Page Count	3
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279621
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Kirchhoff's Law Heart Pharmaceuticals Voltage Muscles Cooling Oils Amino acids Protection Ischemic pain
Content Type	Text
Resource Type	Article

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