NDLI: Gender differences in cardiac electrophysiology

Content Provider	IEEE Xplore Digital Library
Author	Verkerk, A.O. Wilders, R. Tan, H.L.
Copyright Year	2003
Description	Author affiliation: Dept. of Physiol., Amsterdam Univ., Netherlands (Verkerk, A.O.; Wilders, R.)
Abstract	Gender differences in electrocardiographic (ECG) variables and incidence of cardiac arrhythmias exist. Females have longer rate-corrected QT (QTc) intervals and are more susceptible than males to arrhythmias caused by QT prolongation. These observations indicate that fundamental gender differences in electrophysiologic properties exist. Previous experimental studies have provided supportive evidence for this concept, as they have shown gender disparity in the expression and density of some of the major sarcolemmal ion currents that control cardiac excitability, i.e., transient outward K/sup +/ current (I/sub to/), rapid delayed rectifier K/sup +/ current (I/sub Kr/), and L-type Ca/sup 2+/ current (I/sub Ca,L/). In the present study, we evaluated the role of gender-related differences in I/sub to/, I/sub Kr/, and I/sub Ca,L/ densities on cellular cardiac (patho)electrophysiology. We modified ion current amplitudes in the Priebe and Beuckelmann (PB) human ventricular model cell according to experimental data obtained from male and female hearts, and studied action potentials and the susceptibility to arrhythmias. We found that the "female" model cell has longer action potentials, a higher "notch' level, a steeper action potential duration (APD) vs. frequency relationship, and an enhanced susceptibility to early afterdepolarizations. These findings may explain the clinical findings of gender differences in cardiac (patho)electrophysiology.
Sponsorship	Whitaker Found
Starting Page	44
Ending Page	47
File Size	400743
Page Count	4
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279497
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Rectifiers Heart rate Heart rate interval Electrocardiography Indium tin oxide Delay Humans Biomembranes Current density Physiology
Content Type	Text
Resource Type	Article

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