NDLI: Frequency-based analysis of diastolic function

Content Provider	IEEE Xplore Digital Library
Author	Wu, Y. Bowman, A. Chung, C. Karamanoglu, M. Kovacs, S.J.
Copyright Year	2003
Description	Author affiliation: Cardiovascular Biophys. Lab., Washington Univ., St. Louis, MO, USA (Wu, Y.; Bowman, A.; Chung, C.; Karamanoglu, M.; Kovacs, S.J.)
Abstract	Quantitative determination of the filling (diastolic) function of the heart has been primarily correlative rather than causal and has been thwarted by the inability to define sensitive and specific non-invasive numerical indexes. In analogy to impedance, Z(/spl omega/)=V(/spl omega/)/I(/spl omega/) relating voltage V to current I in circuit theory, we introduce the concept of frequency-based analysis of diastolic function (DF) by analyzing the left ventricular (LV) filling pressure (P) to flow(Q) relation in terms of impedance as, Z(/spl omega/)=P(/spl omega/)/Q(/spl omega/). This allows abnormal DF to be viewed as a state of impedance mismatch between pressure and flow, relative to normal. Simultaneous pressure-flow data in 11 subjects was recorded during catheterization. Analysis of variance between groups (ANOVA) shows that the direct current (DC) component of impedance, Z/sub 0/ and the first harmonic coefficient, Z/sub 1/, differentiated between normal and abnormal DF groups (p<0.05). We conclude frequency-based analysis of DF differentiates between normal and abnormal DF states, elucidates the physiology of normal filling as a low-pass filter and has potential as a method for noninvasive DF quantitation.
Sponsorship	Whitaker Found
Starting Page	107
Ending Page	110
File Size	393401
Page Count	4
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279522
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Frequency Impedance Filling Analysis of variance Heart Voltage Circuit theory Catheterization Power harmonic filters Physiology
Content Type	Text
Resource Type	Article

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