NDLI: A computational model of upper airway collapsibility

Content Provider	IEEE Xplore Digital Library
Author	Huang, Y. Malhotra, A. White, D.P.
Copyright Year	2003
Description	Author affiliation: Dept. of Medicine, Brigham & Women's Hosp., MA, USA (Huang, Y.; Malhotra, A.; White, D.P.)
Abstract	A computational model is being developed to investigate pharyngeal collapsibility, pertinent to obstructive sleep apnea. The geometrical structure of the pharyngeal airway is constructed from mid-sagittal plane MR images from normal subjects. The genioglossal muscle activation is simulated by a pressure and state dependent contraction module. This model establishes a direct connection between the contractile forces and the measured electromyogram signals at various upper airway conditions and effectively avoids the difficulty in determining the muscle shortening velocity at complex pharyngeal conditions when modeling muscle contractions. Using the finite element method, we simulate the genioglossal muscle activation behaviors and mimic air flow, tissue deformation and collapse under negative pharyngeal pressures. Using our model, we simulate mandibular advancement and show it to change the collapsibility markedly. A 1-cm advancement decreases pharyngeal closing pressure from -13 to about -20 cmH/sub 2/O. The present study shows that a realistic computational model can simulate pharyngeal collapsibility and potentially improve the treatment of sleep apnea.
Sponsorship	Whitaker Found
File Size	105948
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279656
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computational modeling Muscles Sleep apnea Biomedical imaging Humans Finite element methods Animals Hospitals Medical simulation Force measurement
Content Type	Text
Resource Type	Article

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