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Content Provider | IEEE Xplore Digital Library |
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Author | Roy, P. Bal, A. Patra, M.R. Rahaman, H. Dasgupta, P. |
Copyright Year | 2014 |
Description | Author affiliation: Indian Inst. of Manage., Kolkata, India (Dasgupta, P.) || Sch. of VLSI Technol., Bengal Eng. & Sci. Univ., Shibpur, India (Roy, P.; Bal, A.; Patra, M.R.; Rahaman, H.) |
Abstract | Digital Microfluidic Biochips (DMFB), a promising platform for Lab-on-chip systems are capable of automated biochemical analysis targeted for medical diagnostics and other biochemical applications. The inherent nature of reconfigurability and scalability enables the device to integrate multiple bioassay protocols within the same array for simultaneous execution. Each execution of Bioassay involves numerous microfluidic operations to be performed successfully within the DMFB. Optical Detection and analysis are one of the significant operations required to be performed in DMFB systems for conclusive diagnosis and testing of targeted parameters within the specified sample. In this paper we propose a new design for automated detection based analyzer system integrated with a multipartioned scalable DMFB for two stage confirmatory detection of multiple parameters for a given set of samples .Multiple bioassays are executed sequentially in two stages and the results are analyzed using an intelligent system with integrated memory containing precharacterized standard outputs. The design prototype is implemented on FPGA platform and the simulations and detection results for a set of specified bioassay protocols are found to be satisfactory and in conformance with conventional benchtop laboratory processes. |
Sponsorship | IEEE Circuits Syst. Soc. |
Starting Page | 1836 |
Ending Page | 1840 |
File Size | 1303205 |
Page Count | 5 |
File Format | |
e-ISBN | 9781479934324 |
DOI | 10.1109/ISCAS.2014.6865515 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2014-06-01 |
Publisher Place | Australia |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Microfluidics Biomedical optical imaging Optical sensors Protocols Photodiodes Sugar Registers Intelligent sysrems Digital Microfluidic Biochips Optical detection automated multistage analysis Bioassay integration Digital design |
Content Type | Text |
Resource Type | Article |
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