NDLI: Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

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Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

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Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Olsson, M. Y. Kärre, K. Sentman, C. L.
Description	Author Affiliation: Olsson MY ( Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.);
Abstract	The Ly-49 molecule has been shown to interact with major histocompatibility complex (MHC) class I molecules, and the lytic function of Ly-49+ natural killer (NK) cells from C57BL/6 (H-2b) mice is inhibited by the recognition of H-2Dd on tumor target cells. Introduction of a Ly-49 ligand, H-2Dd, into C57BL/6 mice did not alter the percentage of Ly-49+ NK cells (13-18%), but it led to three functional effects on this subset. (i) The Ly-49 expression in the positive population was reduced by 30-50% compared to C57BL/6 control mice. (ii) While this Ly-49+ subset (Ly-49lo) in the transgenic mice failed to kill BALB/c concanavalin A (Con A) blasts, which have high H-2Dd expression, it was capable of killing SP2/0 tumor cells, which have low H-2Dd expression. Ly-49+ NK cells (Ly-49hi) from nontransgenic mice failed to kill both of these H-2Dd-expressing target cells. (iii) In the transgenic mice, the Ly-49+ subset acquired the ability to kill C57BL/6 Con A blasts, in contrast to the Ly-49+ NK cells of C57BL/6 mice. We propose a 'receptor-calibration' hypothesis, where low receptor density on the effector cells imposed by selection or adaptation to the environment allows higher sensitivity for detection of reduced self-MHC ligands on potential target cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Ly H-2 Antigens Immunology Histocompatibility Antigens Class I Physiology Killer Cells, Natural Lymphocyte Subsets Membrane Glycoproteins Receptors, Immunologic Animals Cytotoxicity, Immunologic Immunity, Cellular Lectins, C-Type Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Knockout Mice, Transgenic Receptors, NK Cell Lectin-Like Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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