NDLI: Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

Please wait, while we are loading the content...

A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness.

Fas expression on antigen-specific T cells has costimulatory, helper and downregulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses

IL-23 promotes maintenance but not commitment to the Th17 lineage.

OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells.

Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity.

Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.

Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells.

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.

Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition.

Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.

n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation.

Loss of protein kinase C theta, Bcl10, or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset.

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

Ikaros regulates Notch target gene expression in developing thymocytes.

Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1.

Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization.

An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation.

Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.

Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.

Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis.

Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.

MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen.

Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses.

Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses.

Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects.

Strategic nonmyeloablative conditioning: CD154:CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure.

Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.

Year: 2008 Volume: 181 Issue: 8

Year: 2008 Volume: 181 Issue: 7

Year: 2008 Volume: 181 Issue: 6

Year: 2008 Volume: 181 Issue: 5

Year: 2008 Volume: 181 Issue: 4

Year: 2008 Volume: 181 Issue: 3

Year: 2008 Volume: 181 Issue: 2

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Falahati, Rustom Leitenberg, David
Description	Country affiliation: United States Author Affiliation: Falahati R ( Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, DC 20037, USA.)
Abstract	In CD45-deficient animals, there is a severe defect in thymocyte-positive selection, resulting in an absence of mature T cells and the accumulation of thymocytes at the DP stage of development. However, the signaling defect(s) responsible for the block in development of mature single-positive T cells is not well characterized. Previous studies have found that early signal transduction events in CD45-deficient cell lines and thymocytes are markedly diminished following stimulation with anti-CD3. Nevertheless, there are also situations in which T cell activation and TCR signaling events can be induced in the absence of CD45. For example, CD45-independent TCR signaling can be recovered upon simultaneous Ab cross-linking of CD3 and CD4 compared with cross-linking of CD3 alone. These data suggest that CD45 may differentially regulate TCR signaling events depending on the nature of the signal and/or on the differentiation state of the cell. In the current study, we have assessed the role of CD45 in regulating primary thymocyte activation following physiologic stimulation with peptide. Unlike CD3-mediated stimulation, peptide stimulation of CD45-deficient thymocytes induces diminished, but readily detectable TCR-mediated signaling events, such as phosphorylation of TCR-associated zeta, ZAP70, linker for activation of T cells, and Akt, and increased intracellular calcium concentration. In contrast, phosphorylation of ERK, which is essential for positive selection, is more severely affected in the absence of CD45. These data suggest that CD45 has a selective role in regulating different aspects of T cell activation.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd45 Physiology Cell Differentiation Immunology Protein Tyrosine Phosphatases Receptors, Antigen, T-cell Signal Transduction Thymus Gland Enzymology Amino Acid Sequence Animals Deficiency Genetics Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Molecular Sequence Data T-lymphocytes Cytology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.

Phospholipase CÎ³2 plays a role in TCR signal transduction and T cell selection.

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.

Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.

Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.

PTPN22 alters the development of regulatory T cells in the thymus.

Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

Similar Documents

Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.

Phospholipase CÎ³2 plays a role in TCR signal transduction and T cell selection.

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.

Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.

Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection.

The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.

Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.

PTPN22 alters the development of regulatory T cells in the thymus.

Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.