NDLI: Sulforaphane promotes immune responses in a WEHI3induced leukemia mouse model through enhanced phagocytosis of macrophages and natural killer cell activities in vivo.

Please wait, while we are loading the content...

Year: 2017 Volume: 15

Year: 2016 Volume: 14

Year: 2016 Volume: 13

Year: 2016 Volume: 13 Issue: 6

Year: 2016 Volume: 13 Issue: 5

Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo.

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.

Expression of MIF and c-erbB-2 in endometrial cancer.

Osteo-/odontogenic differentiation of BMP2 and VEGF gene-co-transfected human stem cells from apical papilla.

MicroRNA-335-5p inhibits osteoblast apoptosis induced by high glucose.

MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a.

Rubus coreanus Miquel extract causes apoptosis of doxorubicin-resistant NCI/ADR-RES ovarian cancer cells via JNK phosphorylation.

S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation

Altered function of monocytes/macrophages in patients with autoimmune hepatitis.

rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis.

The 'selfish brain' is regulated by aquaporins and autophagy under nutrient deprivation.

Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-MB231 breast cancer cells.

X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism: Identification and in vitro study of a novel small indel in the NR0B1 gene.

GGsTOP increases migration of human periodontal ligament cells in vitro via reactive oxygen species pathway.

MicroRNA-29b inhibits TGF-ß1-induced fibrosis via regulation of the TGF-ß1/Smad pathway in primary human endometrial stromal cells.

Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3'-untranslated region of ErbB4 in breast cancer.

Knockdown of ANXA1 suppresses the biological behavior of human NSCLC cells in vitro.

Expression profile analysis of head and neck squamous cell carcinomas using data from The Cancer Genome Atlas.

Whole-genome re-sequencing for the identification of high contribution susceptibility gene variants in patients with type 2 diabetes.

Lazaroid U83836E protects the heart against ischemia reperfusion injury via inhibition of oxidative stress and activation of PKC.

Extracts of Bauhinia championii (Benth.) Benth. attenuate the inï¬ ammatory response in a rat model of collagen-induced arthritis.

Correlation between insulinlike growth factor binding protein 3 and metastasisassociated gene 1 protein in esophageal squamous cell carcinoma.

PageRank analysis reveals topologically expressed genes correspond to psoriasis and their functions are associated with apoptosis resistance.

p38 mitogen-activated protein kinase inhibition modulates nucleus pulposus cell apoptosis in spontaneous resorption of herniated intervertebral discs: An experimental study in rats.

Chemical chaperone 4-phenylbutyric acid protects H9c2 cardiomyocytes from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis.

Screening for genes and subnetworks associated with pancreatic cancer based on the gene expression profile.

Inhibition of RANKL-induced osteoclast differentiation through the downregulation of c-Fos and NFATc1 by Eremochloa ophiuroides (centipedegrass) extract.

MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1.

Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.

CGRP may regulate bone metabolism through stimulating osteoblast differentiation and inhibiting osteoclast formation.

Profiling lethal factor interacting proteins from human stomach using T7 phage display screening.

Attenuation of liver fibrosis by herbal compound 861 via upregulation of BMP-7/Smad signaling in the bile duct ligation model rat.

Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy.

Anticancer effect of docetaxel induces apoptosis of prostate cancer via the cofilin-1 and paxillin signaling pathway.

Maternal undernutrition leads to elevated hepatic triglycerides in male rat offspring due to increased expression of lipoprotein lipase.

shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis.

Cathelicidin-related antimicrobial peptide modulates the severity of acute pancreatitis in mice.

Hypoxia is important in F18 FDG accumulation in thecomafibroma tumors on F18 FDG PET/CT scans.

Lycopene protects human SHSY5Y neuroblastoma cells against hydrogen peroxideinduced death via inhibition of oxidative stress and mitochondriaassociated apoptotic pathways.

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

miR30a5p in the tumorigenesis of renal cell carcinoma: A tumor suppressive microRNA.

Antiadipogenic effects of subthermal electric stimulation at 448 kHz on differentiating human mesenchymal stem cells.

Coinhibition of miRNA21 and miRNA221 induces apoptosis by enhancing the p53mediated expression of proapoptotic miRNAs in laryngeal squamous cell carcinoma.

Knockdown of Nogo gene by short hairpin RNA interference promotes functional recovery of spinal cord injury in a rat model.

Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients.

Inhibition of histone deacetylases by trans-cinnamic acid and its antitumor effect against colon cancer xenografts in athymic mice.

Nuclear respiratory factor 1 overexpression attenuates anti-benzopyrene7,8-diol-9,10-epoxide-induced S-phase arrest of bronchial epithelial cells.

Co-culture with podoplanin+ cells protects leukemic blast cells with leukemia-associated antigens in the tumor microenvironment.

Protective effect of berberine on doxorubicininduced acute hepatorenal toxicity in rats.

Effects of resveratrol and genistein on nuclear factorκB, tumor necrosis factor and matrix metalloproteinase9 in patients with chronic obstructive pulmonary disease.

Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats.

miR19a3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.

Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells.

Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.

Vagus nerve electrical stimulation inhibits serum levels of S100A8 protein in septic shock rats.

Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinoma.

miR1405p regulates angiogenesis following ischemic stroke by targeting VEGFA.

MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1 -promoted glycolysis in non-small cell lung cancer cells.

Role of estrogen receptor in breast cancer cell gene expression.

A comparative study of the timecourse of the expression of the thermoinducible HSP70 gene in clinical and environmental isolates of Aspergillus fumigatus.

Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect.

NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity.

Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumininduced lung inflammation in a murine model of asthma.

Knockdown of SCARA5 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of the PDGF signaling pathway.

TBX5 loss-of-function mutation contributes to atrial fibrillation and atypical Holt-Oram syndrome.

Inhibition of the translocation and extracellular release of high-mobility group box 1 alleviates liver damage in fibrotic mice in response to D-galactosamine/lipopolysaccharide challenge.

Time-dependent activity of Na+/H+ exchanger isoform 1 and homeostasis of intracellular pH in astrocytes exposed to CoCl2 treatment.

Inhibition of mTOR signaling protects photoreceptor cells against serum deprivation by reducing oxidative stress and inducing G2/M cell cycle arrest.

Transcription factormicroRNA synergistic regulatory network revealing the mechanism of polycystic ovary syndrome.

Functionally conserved effects of rapamycin exposure on zebrafish.

Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway.

Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords.

Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling

Upregulation of long non coding RNA PCAT-1 contributes to cell proliferation, migration and apoptosis in hepatocellular carcinoma.

Effect of growth differentiation factor9 C447T and G546A polymorphisms on the outcomes of in vitro fertilization.

Role of N-acetylgalactosaminyltransferase 6 in early tumorigenesis and formation of metastasis.

Sulforaphane promotes immune responses in a WEHI3induced leukemia mouse model through enhanced phagocytosis of macrophages and natural killer cell activities in vivo.

Disrupted intestinal structure in a rat model of intermittent hypoxia.

Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.

IL6 and IL8 enhance factor H binding to the cell membranes.

Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study.

Fibulin-3 may improve vascular health through inhibition of MMP-2/9 and oxidative stress in spontaneously hypertensive rats.

MicroRNA-197 inhibits cell proliferation by targeting GAB2 in glioblastoma.

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model.

Expression patterns of Wnt signaling component, secreted frizzledrelated protein 3 in astrocytoma and glioblastoma.

Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.

Characteristics of B cellassociated gene expression in patients with coronary artery disease.

The cyclic AMP signaling pathway: Exploring targets for successful drug discovery (Review).

Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3.

Translational informatics approach for identifying the functional molecular communicators linking coronary artery disease, infection and inflammation.

Curcumin induces G2/M arrest and triggers apoptosis via FoxO1 signaling in U87 human glioma cells.

Gene expression profile analysis of pancreatic cancer based on microarray data.

Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis.

Role of extracellular signalregulated kinase 1/2 signal transduction pathway in insulin secretion by ßTC6 cells.

3-Deoxyglucosone induces insulin resistance by impairing insulin signaling in HepG2 cells.

Metabolic profiling of Shu-Yu capsule in rat serum based on metabolic fingerprinting analysis using HPLC-ESI-MSn.

Nox4 has a crucial role in uric acidinduced oxidative stress and apoptosis in renal tubular cells.

Antiinflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages.

CXCL12/CXCR4 signaling pathway regulates cochlear development in neonatal mice.

Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis.

Differential expression of EBV proteins LMP1 and BHFR1 in EBVassociated gastric and nasopharyngeal cancer tissues.

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.

Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia.

Effects of NOX1 on fibroblastic changes of endothelial cells in radiationinduced pulmonary fibrosis.

Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.

Year: 2016 Volume: 13 Issue: 4

Year: 2016 Volume: 13 Issue: 3

Year: 2016 Volume: 13 Issue: 2

Year: 2016 Volume: 13 Issue: 1

Year: 2015 Volume: 12

Year: 2015 Volume: 11

Year: 2014 Volume: 10

Year: 2014 Volume: 9

Year: 2013 Volume: 8

Year: 2013 Volume: 7

Year: 2012 Volume: 6

Year: 2012 Volume: 5

Year: 2011 Volume: 4

Year: 2010 Volume: 3

Year: 2008 Volume: 1

Sulforaphane promotes immune responses in a WEHI3induced leukemia mouse model through enhanced phagocytosis of macrophages and natural killer cell activities in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hsueh, Shu-Ching Shih, Yung-Luen Wu, Lung-Yuan Liao, Nien-Chieh Lee, Ching-Hsiao Lu, Hsu-Feng Chen, Yung-Liang Chung, Jing-Gung
Description	Author Affiliation: Shih YL ( Department of Pathology and Laboratory Medicine, Shin Kong Wu HoSu Memorial Hospital, Shihlin, Taipei 11101, Taiwan, R.O.C.); Wu LY ( School of Chinese Medicine for Post Baccalaureate, IShou University, Yanchao, Kaohsiung 824, Taiwan, R.O.C.); Lee CH ( Department of Medical Technology, JenTeh Junior College of Medicine, Nursing and Management, Houlong, Miaoli 360, Taiwan, R.O.C.); Chen YL ( Department of Medical Laboratory Science and Biotechnology, Yuanpei University, Xiangshan, Hsinchu 30015, Taiwan, R.O.C.); Hsueh SC ( Department of Clinical Pathology, Cheng Hsin General Hospital, Beitou, Taipei 112, Taiwan, R.O.C.); Lu HF ( Department of Clinical Pathology, Cheng Hsin General Hospital, Beitou, Taipei 112, Taiwan, R.O.C.); Liao NC ( Department of Medical Technology, JenTeh Junior College of Medicine, Nursing and Management, Houlong, Miaoli 360, Taiwan, R.O.C.); Chung JG ( Department of Biological Science and Technology, China Medical University, Wufeng, Taichung 404, Taiwan, R.O.C.)
Abstract	Sulforaphane (SFN) is an isothiocyanate, inducing cytotoxic effects in various human cancer cells, including leukemia cells through cell cycle arrest and apoptosis. However, the effect of SFN on the immune responses in a leukemia mouse model remains to be investigated. The present study investigated whether SFN has an effect on the immune responses in a WEHI3induced leukemia mouse model in vivo. Normal BALB/c mice were injected with WEHI3 cells to generate the leukemia mouse model, and were subsequently treated with placebo or SFN (0, 285, 570 and 1,140 mg/kg) for 3 weeks. Following treatment, all mice were weighted and blood samples were collected. In addition, liver and spleen samples were isolated to determine cell markers, phagocytosis and natural killer (NK) cell activities, and cell proliferation was examined using flow cytometry. The results indicated that SFN treatment had no significant effect on the spleen weight, however it decreased liver and body weight. Furthermore, SFN treatment increased the percentage levels of CD3 (T cells) and CD19 (B cell maker), however had no effect on the levels of CD11b (monocytes) or Mac3 (macrophages), compared with the WEHI3 control groups. The administration of SFN increased the phagocytosis of macrophages from peripheral blood mononuclear cells and peritoneal cavity, and increased the activity of NK cells from splenocytes. Administration of SFN promoted T and B cell proliferation following stimulation with concanavalin A and lipopolysaccharide, respectively.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in