NDLI: Translational informatics approach for identifying the functional molecular communicators linking coronary artery disease, infection and inflammation.

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Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo.

Melatonin attenuates hLRRK2-induced sleep disturbances and synaptic dysfunction in a Drosophila model of Parkinson's disease.

Expression of MIF and c-erbB-2 in endometrial cancer.

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MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a.

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S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylation

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Protective effect of berberine on doxorubicininduced acute hepatorenal toxicity in rats.

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Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive rats.

miR19a3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion.

Construction of SET overexpression vector and its effects on the proliferation and apoptosis of 293T cells.

Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.

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miR1405p regulates angiogenesis following ischemic stroke by targeting VEGFA.

MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1 -promoted glycolysis in non-small cell lung cancer cells.

Role of estrogen receptor in breast cancer cell gene expression.

A comparative study of the timecourse of the expression of the thermoinducible HSP70 gene in clinical and environmental isolates of Aspergillus fumigatus.

Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect.

NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity.

Inhibitory effect of Zanthoxylum bungeanum seed oil on ovalbumininduced lung inflammation in a murine model of asthma.

Knockdown of SCARA5 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration through suppression of the PDGF signaling pathway.

TBX5 loss-of-function mutation contributes to atrial fibrillation and atypical Holt-Oram syndrome.

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Transcription factormicroRNA synergistic regulatory network revealing the mechanism of polycystic ovary syndrome.

Functionally conserved effects of rapamycin exposure on zebrafish.

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Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords.

Neutrophil elastase enhances the proliferation and decreases apoptosis of leukemia cells via activation of PI3K/Akt signaling

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Effect of growth differentiation factor9 C447T and G546A polymorphisms on the outcomes of in vitro fertilization.

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Expression patterns of Wnt signaling component, secreted frizzledrelated protein 3 in astrocytoma and glioblastoma.

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Translational informatics approach for identifying the functional molecular communicators linking coronary artery disease, infection and inflammation.

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Gene expression profile analysis of pancreatic cancer based on microarray data.

Resistance of mitochondrial DNA-depleted cells against oxidized low-density lipoprotein-induced macrophage pyroptosis.

Role of extracellular signalregulated kinase 1/2 signal transduction pathway in insulin secretion by ßTC6 cells.

3-Deoxyglucosone induces insulin resistance by impairing insulin signaling in HepG2 cells.

Metabolic profiling of Shu-Yu capsule in rat serum based on metabolic fingerprinting analysis using HPLC-ESI-MSn.

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Antiinflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages.

CXCL12/CXCR4 signaling pathway regulates cochlear development in neonatal mice.

Effect of ATRA on the expression of HOXA5 gene in K562 cells and its relationship with cell cycle and apoptosis.

Differential expression of EBV proteins LMP1 and BHFR1 in EBVassociated gastric and nasopharyngeal cancer tissues.

Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells.

Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia.

Effects of NOX1 on fibroblastic changes of endothelial cells in radiationinduced pulmonary fibrosis.

Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway.

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Translational informatics approach for identifying the functional molecular communicators linking coronary artery disease, infection and inflammation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ghatge, Madankumar Vangala, Rajani Kanth Sharma, Ankit Mundkur, Lakshmi
Description	Country affiliation: India Author Affiliation: Sharma A ( Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, Karnataka 560099, India.); Ghatge M ( Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, Karnataka 560099, India.); Mundkur L ( Molecular Immunology Unit, Thrombosis Research Institute, Bangalore, Karnataka 560099, India.); Vangala RK ( Proteomics and Coagulation Unit, Thrombosis Research Institute, Bangalore, Karnataka 560099, India.)
Abstract	Translational informatics approaches are required for the integration of diverse and accumulating data to enable the administration of effective translational medicine specifically in complex diseases such as coronary artery disease (CAD). In the current study, a novel approach for elucidating the association between infection, inflammation and CAD was used. Genes for CAD were collected from the CADgene database and those for infection and inflammation were collected from the UniProt database. The cytomegalovirus (CMV)induced genes were identified from the literature and the CADassociated clinical phenotypes were obtained from the Unified Medical Language System. A total of 55 gene ontologies (GO) termed functional communicator ontologies were identified in the gene sets linking clinical phenotypes in the diseasome network. The network topology analysis suggested that important functions including viral entry, cell adhesion, apoptosis, inflammatory and immune responses networked with clinical phenotypes. Microarray data was extracted from the Gene Expression Omnibus (dataset: GSE48060) for highly networked disease myocardial infarction. Further analysis of differentially expressed genes and their GO terms suggested that CMV infection may trigger a xenobiotic response, oxidative stress, inflammation and immune modulation. Notably, the current study identified Î³glutamyl transferase (GGT)5 as a potential biomarker with an odds ratio of 1.947, which increased to 2.561 following the addition of CMV and CMVneutralizing antibody (CMVNA) titers. The Cstatistics increased from 0.530 for conventional risk factors (CRFs) to 0.711 for GGT in combination with the above mentioned infections and CRFs. Therefore, the translational informatics approach used in the current study identified a potential molecular mechanism for CMV infection in CAD, and a potential biomarker for risk prediction.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5013
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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