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Altered function of monocytes/macrophages in patients with autoimmune hepatitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhou, Lu Lin, Rui Zhang, Jie Wang, Bangmao
Description	Author Affiliation: Lin R ( Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China.); Zhang J ( Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China.); Zhou L ( Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China.); Wang B ( Department of Digestive Diseases, General Hospital, Tianjin Medical University, Tianjin 300052, P.R. China.)
Abstract	The pathogenesis of autoimmune hepatitis (AIH) involves the intervention of the innate and adaptive immune responses. In the current study, the alterations in monocytes/Kupffer cells (KCs) were investigated in patients with AIH. A total of 21 patients with AIH at different stages of the disease, and 7 controls with nonalcoholic fatty liver disease were selected. The abundance of VAV1 and p21activated kinase 1 (PAK1) in the liver and KCs was analyzed. In addition, the expression levels of HLADR and CD80 in the peripheral blood monocytes (PBMs) were measured, and phagocytosis of PBMs was assessed. KCs of AIH patients exhibited higher expression levels of VAV1 and PAK1. This upregulated expression was associated with disease progression. A reduced expression of HLADR and CD80, and reduced capacity of E. coli phagocytosis in PBMs was observed for patients with AIH. This downregulated expression was associated with disease progression. The results of the current study indicated that defective function of KCs and PBMs may be involved in the pathogenesis of AIH.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.4998
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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