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Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.

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Expression of SOFAT by T- and B-lineage cells may contribute to bone loss.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martinez, Elizabeth F. Napimoga, Marcelo H. Sacramento, Laís A. Weitzmann, M. Neale Peruzzo, Daiane C. Jarry, Christian R. Araújo, Vera C. Carregaro, Vanessa
Description	Country affiliation: Brazil Author Affiliation: Jarry CR ( Periodontal Medicine Research Group, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045755, Brazil.); Martinez EF ( Laboratory of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045755, Brazil.); Peruzzo DC ( Periodontal Medicine Research Group, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045755, Brazil.); Carregaro V ( Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil.); Sacramento LA ( Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo 14049-900, Brazil.); Araújo VC ( Laboratory of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045755, Brazil.); Weitzmann MN ( Atlanta Department of Veterans Affairs Medical Center, Decatur, GA 30033, USA.); Napimoga MH ( Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo 13045755, Brazil.)
Abstract	A novel T cell-secreted cytokine, termed secreted osteoclastogenic factor of activated T cells (SOFAT) that induces osteoclastic bone resorption in a RANKL-independent manner, has been described. Our group have previously reported that SOFAT is highly expressed in gingival tissues of patients with chronic periodontitis suggesting a putative role in the bone loss associated with periodontal disease. The aim of the present study was to identify other potential cellular sources of SOFAT in the bone resorptive lesions of patients with periodontal disease. Gingival tissues were biopsied from systemically healthy subjects without periodontal disease (n=5) and patients with chronic periodontitis (n=5), and the presence of SOFAT was analyzed by immunohistochemistry and immunofluorescence staining. The present data demonstrated marked SOFAT staining in diseased periodontal tissues that was predominantly associated with the lymphocytic infiltration of gingival tissues. Notably, in addition to CD3+ T cells, Blineage cells including plasma cells also exhibited strong staining for SOFAT. As SOFAT has not previously been reported in Blineage cells, splenic T cells and B cells were further purified from BALB/c mice and activated using CD3/CD28 and lipopolysaccharide, respectively. SOFAT was quantified by reverse transcriptionquantitative polymerase chain reaction and was shown to be significantly expressed (P<0.05) in both activated T cells and B cells compared with unstimulated cells. These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. In addition, to the best of our knowledge, this study demonstrates for the first time that in addition to T cells, B-lineage cells may also be a significant source of SOFAT in inflammatory states.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5045
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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