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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Xu, Jing Niu, Ting |
| Abstract | Despite considerable progress has been achieved in the treatment of acute myeloid leukemia over the past decades, relapse remains a major problem. Novel therapeutic options aimed at attaining minimal residual disease-negative complete remission are expected to reduce the incidence of relapse and prolong survival. Natural killer cell-based immunotherapy is put forward as an option to tackle the unmet clinical needs. There have been an increasing number of therapeutic dimensions ranging from adoptive NK cell transfer, chimeric antigen receptor-modified NK cells, antibodies, cytokines to immunomodulatory drugs. In this review, we will summarize different forms of NK cell-based immunotherapy for AML based on preclinical investigations and clinical trials. |
| Related Links | https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-020-00996-x.pdf |
| Ending Page | 20 |
| Page Count | 20 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17568722 |
| DOI | 10.1186/s13045-020-00996-x |
| Journal | Journal of Hematology & Oncology |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-12-07 |
| Access Restriction | Open |
| Subject Keyword | Oncology Hematology Cancer Research Acute myeloid leukemia Natural killer cells Immunotherapy Adoptive NK cell transfer Chimeric antigen receptor-modified NK cells Antibodies Cytokines |
| Content Type | Text |
| Resource Type | Review |
| Subject | Hematology Cancer Research Oncology Molecular Biology |
| Journal Impact Factor | 29.9/2023 |
| 5-Year Journal Impact Factor | 27.1/2023 |
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