NDLI: Vagus nerve electrical stimulation inhibits serum levels of S100A8 protein in septic shock rats.

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Vagus nerve electrical stimulation inhibits serum levels of S100A8 protein in septic shock rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Xin-Xin Lei, Ming
Description	Author Affiliation: Lei M ( Department of Critical Care Medicine, Shanghai Seventh People's Hospital, Shanghai 200137, P.R. China.); Liu XX ( Shanghai Institute of Medical Genetics, Shanghai Children's Hospital Affiliated to Shanghai JiaoTong University, Shanghai 200040, P.R. China.)
Abstract	The vagus nerve and the released acetylcholine exert anti-inflammatory effects and inhibit septic shock. However, their detailed mechanisms remain to be elucidated. The present study aimed to investigate the effects of vagus nerve electrical stimulation on serum S100A8 levels in septic shock rats. A total of 36 male Sprague-Dawley rats were randomly divided into six equal groups: i) Sham group, receiving sham operation; ii) CLP group, subjected to cecal ligation and puncture (CLP) to establish a model of polymicrobial sepsis; iii) VGX group, subjected to CLP and bilateral cervical vagotomy; iv) STM group, subjected to CLP, bilateral cervical vagotomy and electrical stimulation on the left vagus nerve trunk; v) bungarotoxin (BGT) group was administered BGT prior to electrical stimulation; vi) Antireceptor for advanced glycation end products (RAGE) group, administered intraperitoneal injection of antiRAGE antibody prior to electrical stimulation. The right carotid artery was cannulated to monitor mean artery pressure (MAP). The serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured to assess the liver function. Serum S100A8 and advanced glycation end product (AGE) levels were measured using enzymelinked immunosorbent assays. The expression of hepatic RAGE was determined by western blotting. The present study revealed that SpragueDawley rats exhibited progressive hypotension and significantly increased serum AST and ALT levels following CLP challenge compared with the sham group. The levels of S100A8 and AGEs, and the protein expression of hepatic RAGE were significantly increased following CLP compared with the sham group. Vagus nerve electrical stimulation significantly prevented the development of CLPinduced hypotension, alleviated the hepatic damage, reduced serum S100A8 and AGEs production, and reduced the expression of hepatic RAGE. The inhibitory effect of vagus nerve electrical stimulation was reversed by pre-treatment with -BGT and enhanced by pre-treatment with anti-RAGE antibody. In conclusion, vagus nerve electrical stimulation may produce a protective effect on septic shock in rats by decreasing the production of S100A8.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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