NDLI: Lycopene protects human SHSY5Y neuroblastoma cells against hydrogen peroxideinduced death via inhibition of oxidative stress and mitochondriaassociated apoptotic pathways.

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Lycopene protects human SHSY5Y neuroblastoma cells against hydrogen peroxideinduced death via inhibition of oxidative stress and mitochondriaassociated apoptotic pathways.

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Lycopene protects human SHSY5Y neuroblastoma cells against hydrogen peroxideinduced death via inhibition of oxidative stress and mitochondriaassociated apoptotic pathways.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ge, Pengfei Feng, Chunsheng Luo, Tianfei Zhang, Yanhong Luo, Yinan Liu, Kai Zhang, Shuyan
Description	Author Affiliation: Feng C ( Department of Anesthesiology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.); Luo T ( Department of Neurology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.); Zhang S ( Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.); Liu K ( Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.); Zhang Y ( Department of Emergent Medicine, People's Hospital of Jilin Province, Changchun, Jilin 130021, P.R. China.); Luo Y ( Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.); Ge P ( Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.)
Abstract	Oxidative stress, which is characterized by excessive production of reactive oxygen species (ROS), is a common pathway that results in neuronal injury or death due to various types of pathological stress. Although lycopene has been identified as a potent antioxidant, its effect on hydrogen peroxide (H2O2)induced neuronal damage remains unclear. In the present study, pretreatment with lycopene was observed to protect SHSY5Y neuroblastoma cells against H2O2induced death via inhibition of apoptosis resulting from activation of caspase3 and translocation of apoptosis inducing factor (AIF) to the nucleus. Furthermore, the overproduced ROS, as well as the reduced activities of antioxidative enzymes, superoxide dismutase and catalase, were demonstrated to be alleviated by lycopene. Additionally, lycopene counteracted H2O2induced mitochondrial dysfunction, which was evidenced by suppression of mitochondrial permeability transition pore opening, attenuation of the decline of the mitochondrial membrane potential, and inhibition of the increase of Bax and decrease of Bcl2 levels within the mitochondria. The release of cytochrome c and AIF from the mitochondria was also reduced. These results indicate that lycopene is a potent neuroprotectant against apoptosis, oxidative stress and mitochondrial dysfunction, and could be administered to prevent neuronal injury or death.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2016.5056
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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