NDLI: Antiinflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages.

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Antiinflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages.

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Antiinflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggisan via enhancement of heme oxygenase1 expression in RAW264.7 macrophages.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoo, Sae-Rom Shin, Hyeun-Kyoo Seo, Chang-Seob Jeong, Soo-Jin Kim, Ohn-Soon Kim, Yeji
Description	Author Affiliation: Jeong SJ ( KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.); Kim OS ( KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.); Yoo SR ( Kherb Research Center, Korea Institute of Oriental Medicine, Daejeon, Chungcheong 34054, Republic of Korea.); Seo CS ( Kherb Research Center, Korea Institute of Oriental Medicine, Daejeon, Chungcheong 34054, Republic of Korea.); Kim Y ( Kherb Research Center, Korea Institute of Oriental Medicine, Daejeon, Chungcheong 34054, Republic of Korea.); Shin HK ( Kherb Research Center, Korea Institute of Oriental Medicine, Daejeon, Chungcheong 34054, Republic of Korea.)
Abstract	Gwakhyangjeonggisan (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrheapredominant irritable bowel syndrome in traditional Korean medicine. In the present study, the antiinflammatory and antioxidant effects of GHJGS were investigated using the RAW 264.7 murine macrophage cell line. GHJGS significantly reduced production of the proinflammatory cytokines, tumor necrosis factor , interleukin6 and prostaglandin E2 in lipopolysaccharide (LPS)stimulated macrophages. GHJGS markedly suppressed LPSinduced phosphorylation of mitogenactivated protein kinases, whereas it had no effect on nuclear factorκB activation. Furthermore, GHJGS enhanced expression of heme oxygenase1 and prevented the generation of reactive oxygen species in RAW 264.7 cells. These results indicate that GHJGS is a viable therapeutic agent against inflammation and oxidative stressassociated disorders.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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