NDLI: Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity.

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Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity.

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Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lin, Jen-Jyh Lin, Ju-Hwa Weng, Shu-Wen Chueh, Fu-Shin Huang, Yi-Ping Chung, Jing-Gung
Description	Author Affiliation: Chueh FS ( Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, R.O.C.); Lin JJ ( School of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.); Lin JH ( Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.); Weng SW ( School of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.); Huang YP ( Department of Physiology, China Medical University, Taichung, Taiwan, R.O.C.); Chung JG ( Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.)
Abstract	Polygonum cuspidatum is a natural plant that is used in traditional Chinese herbal medicine. The crude extract of Polygonum cuspidatum (CEPC) has numerous biological effects; however, there is a lack of studies on the effects of CEPC on immune responses in normal mice. The aim of the present study was to determine the in vivo effects of CEPC on immune responses in normal mice. CEPC (0, 50, 100, 150 and 200 mg/kg) was orally administered to BALB/c mice for three weeks, following which blood, liver, and spleen samples were collected. CEPC did not significantly affect the total body weight, or tissue weights of the liver or spleen, as compared with the control mice. CEPC increased the percentages of CD3 (T-cell marker), 11b (monocytes) and Mac-3 (macrophages) positive-cells, and reduced the percentage of CD19-positive cells (B-cell marker), as compared with the control mice. CEPC (100 mg/kg) stimulated macrophage phagocytosis of blood samples but did not affect macrophage phagocytosis in the peritoneum. Activity of the splenic natural killer cells was increased in response to CEPC (50 mg/kg) treatment. Furthermore, CEPC inhibited T- and B-cell proliferation when the cells were stimulated with concanavalin A and lipopolysaccharide, respectively.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2014.2739
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-01-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cytotoxicity, Immunologic Drug Effects Polygonum Cuspidatum Chemistry Killer Cells, Natural Immunology Macrophages Phagocytosis Plant Extracts Pharmacology Animals Antigens, Differentiation Metabolism Antigens, Surface Body Weight Leukocytes, Mononuclear Lymphocyte Activation Lymphocyte Subsets Mice Organ Size Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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