NDLI: Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.

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Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.

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Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shao, Jie Gan, Linghong Wang, Jie
Description	Author Affiliation: Shao J ( Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.); Gan L ( Department of Nursing, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.); Wang J ( Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.)
Abstract	Breast cancer affects one in every eight women, and has been associated with higher rates of female mortality than any other cancer type, with the exception of lung cancer. It has been reported that chondromodulin I (ChM-I) was able to suppress tumor angiogenesis and growth in vivo. In order to investigate the antitumor action of ChMI on human breast cancer cells, a plasmid expressing ChMI was constructed and transfected into human breast cancer cells using an adenoviral vector. Reverse transcriptionpolymerase chain reaction detected ChMI expression in human breast cancer cell lines, whereas no expression was detected in the control groups. In order to assess the effect of ChMI on human breast cancer cells, cell counting kit8 (CCK8) and colony formation analyses were used to detect tumor cell proliferation, and the proliferation of ChMItransfected cells was significantly reduced, as compared with the control. In addition, the mRNA expression levels of cell cycleassociated genes in ChMItransfected cells were significantly decreased, as compared with the control, which suggested that ChMI transfection was able to inhibit the expression of genes associated with the cell cycle. The results of the present study indicated that ChMI was able to inhibit the growth of breast cancer cells; thus suggesting that ChM-I may have potential clinical applications in the treatment of breast cancer.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	13
Language	English
Publisher	Spandidos Publications
Publisher Date	2016-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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