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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Q. L. Wang, C. F. Li, J. B. Zhao, Z. L. Huang, J. M. Ju, Z. H. Zhong, J. F. Zhang, J. B. |
| Spatial Coverage | China |
| Description | Author Affiliation: Zhao ZL ( College of Animal Husbandry and Veterinary, Jilin University, Changchun, P.R. China.) |
| Abstract | The mannan-binding lectin gene (MBL) participates as an opsonin in the innate immune system of mammals, and single nucleotide polymorphisms (SNPs) in MBL cause various immune dysfunctions. In this study, we detected SNPs in MBL2 at exon 1 using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chinese Holstein cows. Four new SNPs with various allele frequencies were also found. The g.1164 G>A SNP was predicted to substitute arginine with glutamine at the N-terminus of the cysteine-rich domain. In the collagen-like domain, SNPs g.1197 C>A and g.1198 G>A changed proline to glutamine, whereas SNP g.1207 T>C was identified as a synonymous mutation. Correlation analysis showed that the g.1197 C>A marker was significantly correlated to somatic cell score (SCS), and the g.1164 G>A locus had significant effects on SCS, fat content, and protein content (P < 0.05), suggesting possible roles of these SNPs in the host response against mastitis. Nine haplotypes and nine haplotype pairs corresponding to the loci of the 4 novel SNPs were found in Chinese Holsteins. Haplotype pairs MM, MN, and BQ were correlated with the lowest SCS; MN with the highest protein yield; MM with the highest protein rate, and MN with the highest 305- day milk yield. Thus, MM, MN, and BQ are possible candidates for marker-assisted selection in dairy cattle breeding programs. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2012-10-15 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Genetics Genetic Association Studies Mannose-binding Lectin Metabolism Polymorphism, Single Nucleotide Quantitative Trait, Heritable Alleles Amino Acid Sequence Animals Exons Gene Frequency Haplotypes Heterozygote Least-squares Analysis Chemistry Molecular Sequence Data Polymorphism, Single-stranded Conformational Sequence Analysis, Dna Silver Staining Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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