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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Qiu, Q. He, X. S. Chen, Z. C. Hu, B. |
| Description | Country affiliation: China Author Affiliation: Qiu Q ( Cancer Research Institute, University of South China, Hengyang, Hunan, China.) |
| Abstract | STGC3 is a potential tumor suppressor in nasopharyngeal carcinoma. We previously found that CNE2 cells that re-expressed STGC3 formed smaller tumors in female mice than in male mice. Here, we investigated the sexual dimorphism of STGC3 as a tumor-suppressor in female and male nude mice injected subcutaneously with pcDNA3.1(+)-STGC3/CNE2 cells. ER- was positively expressed in vitro in the CNE2 cells. The pcDNA3.1(+)-STGC3/CNE2 cell growth rate decreased after treatment with ß-estradiol in vitro. There were significant differences in tumor size or mass between pcDNA3.1(+)-STGC3/CNE2 and control cases (P < 0.05), but there were significant differences in tumor size between female and male nude mice in the STGC3 transfection groups, and the pcDNA3.1(+)-STGC3/CNE2 tumor growth rate in the female nude mice was the lowest in all cases (P < 0.05). There were no significant differences between female and male nude mice in control groups. Furthermore, a greater number of cells were blocked in the G(0)/G(1) phase in pcDNA3.1(+)-STGC3/ CNE2 tumor xenografts in the female mice. Protemic analysis found 9 differentially expressed proteins in the pcDNA3.1-STGC3/CNE2 xenograft tissues in females and males. A heat shock 70 protein 8 isoform 2 variant was identified as a down-regulated protein associated with cell cycle control and its downstream factor cyclin D1 was also decreased in STGC3-repressed xenografts in female mice. The data above suggest that STGC3 and its associated proteins play an important role in nasopharyngeal carcinoma gender differences. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2012-12-19 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Carcinoma Pathology Genes, Tumor Suppressor Nasopharyngeal Neoplasms Proteins Genetics Animals Metabolism Cell Line, Tumor Cyclin D1 Estradiol Physiology Estrogen Receptor Alpha Hsc70 Heat-shock Proteins Mice Mice, Inbred Balb C Mice, Nude Neoplasm Transplantation G0 Phase Sex Characteristics Sex Factors Transcriptome Tumor Burden Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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