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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, C. L. Liu, Y. L. Wang, P. Li, Y. Z. Zhu, J. W. Yan, S. |
| Description | Country affiliation: China Author Affiliation: Yan S ( Department of Urological Surgery, Fourth Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.) |
| Abstract | We investigated a possible association between CASP-10 gene polymorphisms and susceptibility to cancer through a meta-analysis. Eight studies with a total of 29,936 cancer cases and 34,041 healthy controls were included. Meta-analysis results showed that the rs13006529 T carrier was significantly associated with increased cancer risk (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). However, rs3900115 and rs13010627 showed no association with cancer susceptibility (all P > 0.05). In the subgroup analysis by cancer type, we found that the rs13006529 T carrier was a risk factor for breast cancer (OR = 1.17, 95%CI = 1.01-1.36, P = 0.03). Similarly, no association was found between CASP-10 polymorphisms and susceptibility to lymphoma, myeloma, melanoma, or lung cancer (all P > 0.05). This meta-analysis suggests that the rs13006529 T carrier in the CASP-10 gene might be a risk factor for cancer susceptibility, especially for breast cancer. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2012-11-26 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Caspase 10 Genetics Genome, Human Neoplasms Epidemiology Polymorphism, Single Nucleotide Case-control Studies Genetic Predisposition To Disease Linear Models Odds Ratio Publication Bias Meta-analysis Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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