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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Castro, R. B. Faria, C. D. C. Chamlian, E. G. Melo, M. R. Pereira, W. L. Rocha, M. N. Longui, C. A. Silva, T. S. Richeti, F. Rivetti, L. A. |
| Description | Country affiliation: Brazil Author Affiliation: Castro RB ( Laboratório de Medicina Molecular, Departamento de Fisiologia, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brasil.) |
| Abstract | Insulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases. Glucocorticoids are known determinant factors of insulin resistance. We quantified glucocorticoid receptor alpha (GR ) mRNA and 11 beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) mRNA in various tissues of 35 patients with previously established cardiovascular disease. This was a prospective study in a cardiac surgery patient setting. Samples of subcutaneous adipose tissue, epicardial fat, muscle, and peripheral blood mononuclear cells were examined. GR and 11ß-HSD1 mRNA were determined by real-time PCR. Mean age was 54.4 years. A significantly higher level of GR mRNA was observed in muscle, with mean = 43.6 arbitrary units, median (p25-p75) = 39.4, compared to epicardial adipose tissue, with mean = 34.2, median (p25-p75) = 27.6, and to subcutaneous adipose tissue, with mean = 29.0, median (p25-p75) = 19.0, and lymphocytes, with mean = 17.5, median (p25-p75) = 14.02. When patients with diabetes mellitus were compared to patients without insulin resistance, significantly lower levels of GR mRNA were observed in epicardial fat. Lymphocytes had the lowest 11ß-HSD1 mRNA concentration. We also observed significantly reduced 11ß-HSD1 mRNA levels in visceral fat when compared with muscle tissue. GR and 11ß-HSD1 mRNA levels differed among tissues involved in the pathophysiology of metabolic syndrome. We conclude that epicardial adipose tissue has lower GR mRNA levels in insulin-resistant patients; this seems to be an adaptive and protective mechanism. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2012-11-21 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Adaptation, Physiological Genetics Insulin Resistance Organ Specificity Receptors, Glucocorticoid 11-beta-hydroxysteroid Dehydrogenase Type 1 Metabolism Cardiovascular Diseases Physiopathology Surgery Gene Expression Regulation Intra-abdominal Fat Pathology Pericardium Rna, Messenger Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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