NDLI: Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.

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Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.

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Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Degli-esposti, Mariapia A. Yokoyama, Wayne M. Tonkin, Joanne N. Scalzo, Anthony A. Smith, Hamish R. C. Forbes, Catherine A. Voigt, Valentina
Description	Author Affiliation: Voigt V ( Immunology and Virology Program, Centre for Opthalmology and Visual Science, University of Western Australia, Nedlands, WA 6009, Australia.);
Abstract	Effective natural killer (NK) cell recognition of murine cytomegalovirus (MCMV)-infected cells depends on binding of the Ly49H NK cell activation receptor to the m157 viral glycoprotein. Here we addressed the immunological consequences of variation in m157 sequence and function. We found that most strains of MCMV possess forms of m157 that evade Ly49H-dependent NK cell activation. Importantly, repeated passage of MCMV through resistant Ly49H+ mice resulted in the rapid emergence of m157 mutants that elude Ly49H-dependent NK cell responses. These data provide the first molecular evidence that NK cells can exert sufficient immunological pressure on a DNA virus, such that it undergoes rapid and specific mutation in an NK cell ligand enabling it to evade efficient NK cell surveillance.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Killer Cells, Natural Immunology Muromegalovirus Genetics Mutation Animals Antigens, Ly Cells, Cultured Cytotoxicity, Immunologic DNA Metabolism Fibroblasts Genetic Variation Glycoproteins Chemistry Immunity, Innate Lectins, C-Type Ligands Lymphocyte Subsets Mice Mice, Inbred BALB C Molecular Sequence Data NK Cell Lectin-Like Receptor Subfamily A Polymerase Chain Reaction Receptors, Immunologic Receptors, NK Cell Lectin-Like Spleen Virology Transfection Beta-Galactosidase Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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