NDLI: Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.

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Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.

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Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Freigang, Stefan Bienz, Kurt Zinkernagel, Rolf M. Hengartner, Hans Egger, Denise
Description	Author Affiliation: Freigang S ( Institute of Experimental Immunology, University Hospital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland. feigang@pathol.unizh.ch);
Abstract	Induction of antiviral cytotoxic T lymphocytes (CTLs) has been proposed to require cross-presentation of viral antigens derived from infected extralymphatic host cells by antigen-presenting cells (APC). This postulated mechanism of cross-priming is thought to be essential for CTL responses against viruses that do not infect professional APC, e.g., because of absence of the specific virus receptor. Here, we show for the human pathogen poliovirus that naturally nonpermissive murine APC acquire viral RNA in vivo independently of the cellular virus receptor. Uptake of poliovirus or polioviral RNA initiated neosynthesis of viral antigen to an extent sufficient to prime CTLs in vivo, which were detectable 2-3 wk after infection. Our results do not only indicate that experiments studying cross-presentation and cross-priming by using potentially amplifiable or translatable materials need careful examination, but they also question the general biological importance of cross-presentation and cross-priming in antiviral CTL responses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Viral Chemistry T-Lymphocytes, Cytotoxic Metabolism Virology Animals Antigen Presentation Antigen-Presenting Cells Antigens Antigens, CD11c Biosynthesis Cell Line, Tumor Clostridium Magnetics Mice Mice, Inbred C57BL Poliovirus Poliovirus Vaccines RNA RNA, Messenger RNA, Viral Time Factors Transfection Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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