NDLI: The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.

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The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.

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The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rubin, Gerald M. Serano, Julia
Description	Author Affiliation: Serano J ( Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. serano@uclink4.berkeley.edu);
Abstract	The vertebrate synaptotagmin-like protein granuphilin binds to the vesicle-trafficking proteins Rab27a and Munc18 and can modulate exocytosis of insulin-containing secretory granules in pancreatic beta cell lines. Here, we report the molecular and genetic characterization of bitesize, a granuphilin homolog and the only Drosophila synaptotagmin-like protein. Mutations that affect bitesize have reduced cell size and number, resulting in smaller animals that develop slowly. We also show that at least two classes of bitesize transcripts are localized to the apical plasma membrane in polarized epithelial cells. Whereas most cis-acting mRNA localization sequences map to 3' untranslated regions, bitesize contains a 2.2-kb sequence within its ORF that is necessary and sufficient for apical localization. Thus, we have found that bitesize is a metazoan example of a transcript for which all identifiable mRNA localization sequences are contained within the protein-coding region.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium-Binding Proteins Drosophila Proteins Genetics Physiology Membrane Glycoproteins Membrane Proteins Nerve Tissue Proteins Proteins Metabolism RNA, Messenger Vesicular Transport Proteins Rab GTP-Binding Proteins 3' Untranslated Regions Animals Body Weight Cell Division Cell Membrane DNA, Complementary Drosophila Exocytosis Gene Library Islets Of Langerhans Cytology Models, Genetic Molecular Sequence Data Munc18 Proteins Mutation Open Reading Frames Protein Isoforms Synaptotagmins Transcription, Genetic Transgenes Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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