NDLI: Botulinum toxin type B micromechanosensor.

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Botulinum toxin type B micromechanosensor.

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Botulinum toxin type B micromechanosensor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, W. Montana, Vedrana Chapman, Edwin R. Mohideen, U. Parpura, Vladimir
Description	Author Affiliation: Liu W ( Department of Physics, University of California, Riverside, CA 92521, USA.);
Abstract	Botulinum neurotoxin (BoNT) types A, B, E, and F are toxic to humans; early and rapid detection is essential for adequate medical treatment. Presently available tests for detection of BoNTs, although sensitive, require hours to days. We report a BoNT-B sensor whose properties allow detection of BoNT-B within minutes. The technique relies on the detection of an agarose bead detachment from the tip of a micromachined cantilever resulting from BoNT-B action on its substratum, the synaptic protein synaptobrevin 2, attached to the beads. The mechanical resonance frequency of the cantilever is monitored for the detection. To suspend the bead off the cantilever we use synaptobrevin's molecular interaction with another synaptic protein, syntaxin 1A, that was deposited onto the cantilever tip. Additionally, this bead detachment technique is general and can be used in any displacement reaction, such as in receptor-ligand pairs, where the introduction of one chemical leads to the displacement of another. The technique is of broad interest and will find uses outside toxicology.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Biological Assay Botulinum Toxins Chemistry Metabolism Antigens, Surface Blotting, Western Botulinum Toxins, Type A Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Immunochemistry Membrane Proteins Microscopy, Atomic Force Instrumentation Nerve Tissue Proteins Protein Binding R-SNARE Proteins Recombinant Proteins Sensitivity And Specificity Syntaxin 1 Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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