NDLI: Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.

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Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.

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Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Küster-schöck, Elke Nakano, Shunji Zuber, Peter Grossman, Alan D.
Description	Author Affiliation: Nakano S ( Department of Environmental and Biomolecular Systems, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA.);
Abstract	The Spx protein of Bacillus subtilis represses activator-stimulated transcription by interacting with the C-terminal domain of RNA polymerase (RNAP) alpha subunit. Its concentration increases in cells lacking the ATP-dependent protease, ClpXP, resulting in severe effects on growth and developmental processes. Microarray analysis was undertaken to identify genes that are induced or repressed when Spx interacts with RNAP. The induced genes included those encoding products known to function in maintaining thiol homeostasis. Two genes, thioredoxin (trxA) and thioredoxin reductase (trxB), are transcriptionally induced under conditions of thiol-specific oxidative (disulfide) stress by a mechanism involving Spx-RNAP interaction. Disulfide stress also results in an increase in Spx-dependent transcriptional repression. The increase in Spx activity in cells encountering disulfide stress is due in part to a posttranscriptional mechanism of spx control resulting in an increase in Spx concentration. An spx null mutant and a strain bearing an allele of rpoA that prevents Spx-RNAP interaction show hypersensitivity to disulfide stress. From these results, it is proposed that Spx is an activator that mobilizes the operations necessary to reverse the effects of oxidative damage, but it also serves as a negative regulator that causes the postponement of developmental programs and energy-consuming growth-related functions while the cell copes with the period of stress.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacillus Subtilis Metabolism Oxidative Stress Repressor Proteins Physiology Transcription, Genetic Alleles Amino Acid Sequence Blotting, Western DNA-Directed RNA Polymerases Disulfides Molecular Sequence Data Mutagenesis, Site-Directed Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic RNA, Messenger Thioredoxin-Disulfide Reductase Thioredoxins Time Factors Transcriptional Activation Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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