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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rosenberg, Tzur Skorecki, Karl Ravel, Yael Tzukerman, Maty Reiter, Irena Coleman, Raymond |
| Description | Author Affiliation: Tzukerman M ( Rambam Medical Center and Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel.); |
| Abstract | There is currently no available experimental system wherein human cancer cells can be grown in the context of a mixed population of normal differentiated human cells for testing biological aspects of cancer cell growth (e.g., tumor cell invasion and angiogenesis) or response to anti-cancer therapies. When implanted into immunocompromised mice, human embryonic stem cells develop teratomas containing complex structures comprising differentiated cell types representing the major germ line-derived lineages. We sought to determine whether human cancer cells would grow within such teratomas and display properties associated with malignancy, such as invasiveness and recruitment of blood vessels. HEY ovarian cancer cells stably expressing an H2A-GFP fusion protein (HEY-GFP) injected into mature teratomas developed into tumors, which allowed tracking of tumor cell invasion and recruitment of human teratoma-derived blood vessels. This provides a straightforward and powerful approach to studying the biological properties of cancer cells within the microenvironment of normal differentiated human cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 100 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2003-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Embryo, Mammalian Cytology Neoplasm Transplantation Teratoma Metabolism Animals Antigens, CD31 Biosynthesis Cell Differentiation Cell Division Cell Line Cell Line, Tumor DNA, Complementary Green Fluorescent Proteins Histones Immunohistochemistry Luminescent Proteins Mice Mice, SCID Neoplasm Invasiveness Neovascularization, Pathologic Plasmids Recombinant Fusion Proteins Transfection Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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