NDLI: Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2003 Volume: 100 Issue: 26

Year: 2003 Volume: 100 Issue: 25

Year: 2003 Volume: 100 Issue: 24

Year: 2003 Volume: 100 Issue: 23

Estimating mean lifetime.

An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.

Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAbeta knockout NOD mice.

Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force.

Identification of functional similarities between proteins using directed evolution.

Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice.

Botulinum toxin type B micromechanosensor.

Protein profiles associated with survival in lung adenocarcinoma.

PA-457: a potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing.

An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells.

Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene.

Contribution of climate-driven change in continental water storage to recent sea-level rise.

The proteome of Saccharomyces cerevisiae mitochondria.

Evidence that the bypassing ribosome travels through the coding gap.

Histone sumoylation is associated with transcriptional repression.

Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse.

Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.

Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene.

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.

Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice.

Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network.

Robust singular value decomposition analysis of microarray data.

Abnormal osmotic regulation in trpv4-/- mice.

Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading.

The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.

The two rotor components of yeast mitochondrial ATP synthase are mechanically coupled by subunit δ

Trp-cage: folding free energy landscape in explicit water.

Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation.

Inflammation is detrimental for neurogenesis in adult brain.

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.

Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.

Visualizing the distribution and transport of mRNAs in living cells.

Revealing competitive Forster-type resonance energy-transfer pathways in single bichromophoric molecules.

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor.

Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica.

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate.

The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis.

A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis.

A specific endoribonuclease, RNase P, affects gene expression of polycistronic operon mRNAs.

A comparative study of motor-protein motions by using a simple elastic-network model.

Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nuclease.

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags.

Reevaluation of human cytomegalovirus coding potential.

Extensive repetitive DNA facilitates prokaryotic genome plasticity.

Solution structure of a de novo protein from a designed combinatorial library.

Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.

Posttranscriptional control of the competence factor betaFTZ-F1 by juvenile hormone in the mosquito Aedes aegypti.

Calcium-dependent molecular spring elements in the giant protein titin.

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.

Generation of hair cells by stepwise differentiation of embryonic stem cells.

Src kinase activation by direct interaction with the integrin β cytoplasmic domain

Regulation of CD18 expression on neutrophils in response to fluid shear stress

The anthropoid status of a primate from the late middle Eocene Pondaung Formation (Central Myanmar): tarsal evidence.

Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants.

Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex.

Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.

RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti.

A panoramic view of gene expression in the human kidney.

Aqueous access pathways in subunit a of rotary ATP synthase extend to both sides of the membrane

Normal B-1a cell development requires B cell-intrinsic NFATc1 activity.

Essential role for RGS9 in opiate action.

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.

De novo designed cyclic-peptide heme complexes.

Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway

Boundary of quantum evolution under decoherence.

Unifying features in protein-folding mechanisms.

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.

Invasion, competitive dominance, and resource use by exotic and native California grassland species.

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.

Quantitative trait symmetry independent of Hsp90 buffering: Distinct modes of genetic canalization and developmental stability

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

An emotion-induced retrograde amnesia in humans is amygdala- and beta-adrenergic-dependent.

SecA-dependent quality control of intracellular protein localization.

Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity.

Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis.

Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: the role of the anterior cingulate.

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.

Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoforms.

An endogenous suppressor of hairy-wing insulator separates regulatory domains in Drosophila.

Subadult experience influences adult mate choice in an arthropod: exposed female wolf spiders prefer males of a familiar phenotype.

Reciprocal modulation of phospholipase Cbeta isoforms: adaptation to chronic morphine.

Delayed $K^{+}$ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice

Cytochrome P450 flexibility.

DNA replication of mitotic chromatin in Xenopus egg extracts.

Histone modifications: Now summoning sumoylation.

Biography of John Bongaarts.

Biographies of newly elected Academy members.

Exploring the origins of binding specificity through the computational redesign of calmodulin.

Neural correlates of training-related memory improvement in adulthood and aging.

Discovery of a bacterium, with distinctive dioxygenase, that is responsible for in situ biodegradation in contaminated sediment.

Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation.

Adaptive evolution in the Arabidopsis MADS-box gene family inferred from its complete resolved phylogeny.

The inhibitory potential of Fc receptor homolog 4 on memory B cells

A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.

Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alpha.

Endosomal compartmentalization in three dimensions: implications for membrane fusion.

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance.

Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function.

Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents.

Pannexins, a family of gap junction proteins expressed in brain.

Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.

Motility of Escherichia coli cells in clusters formed by chemotactic aggregation.

Multiple oscillators regulate circadian gene expression in Neurospora.

Similar neural mechanisms for emotion-induced memory impairment and enhancement.

Creation of the first anomeric D/L-sugar kinase by means of directed evolution.

Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam.

Year: 2003 Volume: 100 Issue: 22

Year: 2003 Volume: 100 Issue: 21

Year: 2003 Volume: 100 Issue: 20

Year: 2003 Volume: 100 Issue: 19

Year: 2003 Volume: 100 Issue: 18

Year: 2003 Volume: 100 Issue: 17

Year: 2003 Volume: 100 Issue: 16

Year: 2003 Volume: 100 Issue: 15

Year: 2003 Volume: 100 Issue: 14

Year: 2003 Volume: 100 Issue: 13

Year: 2003 Volume: 100 Issue: 12

Year: 2003 Volume: 100 Issue: 11

Year: 2003 Volume: 100 Issue: 10

Year: 2003 Volume: 100 Issue: 9

Year: 2003 Volume: 100 Issue: 8

Year: 2003 Volume: 100 Issue: 7

Year: 2003 Volume: 100 Issue: 6

Year: 2003 Volume: 100 Issue: 5

Year: 2003 Volume: 100 Issue: 4

Year: 2003 Volume: 100 Issue: 3

Year: 2003 Volume: 100 Issue: 2

Year: 2003 Volume: 100 Issue: Suppl 2

Year: 2003 Volume: 100 Issue: 1

Year: 2003 Volume: 100 Issue: Suppl 1

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Goronzy, Jörg J. Weyand, Cornelia M. Widmann, Thomas Zimmer, Julia Schönland, Stefan O. Bryl, Ewa Lopez, Consuelo
Description	Author Affiliation: Schönland SO ( Department of Medicine and Immunology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.);
Abstract	In rheumatoid arthritis, peripheral blood T cells have age-inappropriate telomeric erosion. We examined whether HLA-DRB104 alleles, the major susceptibility genes for this disease, confer risk for T cell senescence. In healthy individuals, HLA-DRB104 alleles were associated with excessive loss of telomeres in CD4+ T cells. Accelerated telomeric erosion occurred during the first two decades of life and was followed by reduced homeostatic T cell proliferation during adulthood. Premature telomeric loss also affected granulocytes, suggesting that the hematopoietic stem cell is the primary target. Telomeric repair mechanisms were intact in HLA-DRB104+ donors. We propose that HLA-DRB104 alleles or genes in linkage disequilibrium regulate stem cell replication and contribute to the accumulation of senescent and autoreactive T cells in rheumatoid arthritis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Arthritis, Rheumatoid Genetics Lymphocytes Cytology Myeloid Cells Telomere Alleles Antigens, CD28 Biosynthesis Antigens, CD3 CD4-Positive T-Lymphocytes Metabolism Cell Aging Cell Division Cell Lineage DNA Flow Cytometry Genotype Granulocytes HLA-DR Antigens HLA-DRB1 Chains Immunologic Memory Linkage Disequilibrium Models, Biological Ultrastructure Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in