NDLI: The effect of air pollutants on the microecology of the respiratory tract of rats.

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The effect of air pollutants on the microecology of the respiratory tract of rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xiao, Chunling Li, Shuyin Zhou, Weiqiang Shang, Dezhi Zhao, Su Zhu, Xiaomin Chen, Kuimin Wang, Renqun
Description	Author Affiliation: Xiao C ( Department of Pathogen Biology, Shenyang Medical College, No. 146, North Huanghe St, Huanggu Dis, Shenyang City, Liaoning Pro 110034, PR China. xiaochunling@symc.edu.cn)
Abstract	To study the effect of air pollution on the microecology of the respiratory tracts and the relationship of the biotopes with respiratory diseases, Wistar rats exposed to mixed air pollutants were used as poisoning models. The bacterial floras of respiratory tract were analyzed as well as expression of pro-inflammatory mediators of the respiratory epithelium. The mRNA and protein expression levels of pro-inflammatory factor and cytokines measured showed that there were significant changes in the microbiocenosis of the respiratory tract. The microorganisms underwent quantitative and qualitative changes following exposure to mixed air pollutants including a decline of indigenous microflora and increase of the content of conditionally pathogenic microorganisms. These changes depended on the degree of air pollution severity. Measurement of pro-inflammatory factors CC16, TNF- and IL-6 revealed a similar time-dependent relationship between the content of conditionally pathogenic microorganisms and the interference of CC16 secretion, as well as up-expression of TNF- and IL-6.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Air Pollutants Toxicity Pharynx Drug Effects Microbiology Animals Bronchoalveolar Lavage Fluid Immunology Dose-response Relationship, Drug Female Gene Expression Regulation Inflammation Mediators Metabolism Inhalation Exposure Interleukin-6 Genetics Male Rna, Messenger Rats Rats, Wistar Time Factors Tumor Necrosis Factor-alpha Uteroglobin Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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