NDLI: Aroclor 1254 induced oxidative stress and mitochondria mediated apoptosis in adult rat sperm in vitro.

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Aroclor 1254 induced oxidative stress and mitochondria mediated apoptosis in adult rat sperm in vitro.

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Aroclor 1254 induced oxidative stress and mitochondria mediated apoptosis in adult rat sperm in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Aly, Hamdy A. A.
Description	Country affiliation: Saudi Arabia Author Affiliation: Aly HA ( Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia. hamdyaali@yahoo.com)
Abstract	Aroclor 1254, a commercial mixture of highly toxic environmental pollutant, is known to cause testicular toxicity. The present study was undertaken to delineate and elucidate the nature and the mechanism of action of Aroclor 1254 on rat sperm in vitro. Sperm of adult rat were incubated with 10(-9)M, 10(-8)M or 10(-7)M of Aroclor 1254 for 3h. Sperm motility was significantly decreased. Moreover, sperm viability, acrosome reaction and mitochondrial membrane potential (Δψm) were significantly decreased in a dose-related pattern. DNA integrity was significantly decreased at 10(-8)M and 10(-7)M of Aroclor 1254, while it did not show any significant change at 10(-9)M. Aroclor 1254 induced downstream events included cytochrome c release and caspase-3 activation, in a dose-related manner. ATP content was decreased while protein carbonyl content was significantly increased in a dose-related manner. The oxidative stress status was also assessed. Hydrogen peroxide (H2O2) production and lipid peroxidation (LPO) were significantly increased in a dose-related pattern. The antioxidant enzymes SOD, CAT and GPx were significantly decreased, while at a concentration of 10(-9)M of Aroclor 1254, GR activity did not show any significant change. The non-enzymatic antioxidant (GSH) was significantly decreased in a dose-dependent manner. In conclusion; our data clearly show that Aroclor 1254 induces toxicity, oxidative stress and culminating in mitochondria mediated apoptosis in rat sperm.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Apoptosis Drug Effects Toxicity Environmental Pollutants Mitochondria Oxidative Stress Spermatozoa Adenosine Triphosphate Metabolism Animals Caspase 3 Catalase Cell Survival Cytochromes c Dna Damage Dose-response Relationship, Drug Glutathione Peroxidase Hydrogen Peroxide Lipid Peroxidation Male Membrane Potential, Mitochondrial Pathology Protein Carbonylation Rats Rats, Wistar Sperm Motility Superoxide Dismutase Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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