NDLI: Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.

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Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Shixiang Zang, Weijin Yang, Yang Zhang, Qian Zhao, Ming Gao, Zhijuan Li, Gangcheng Meng, Qingnai Liu, Qinshe Zheng, Xiaohui
Description	Author Affiliation: Wang S ( Department of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, PR China.)
Abstract	Benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, is formed by incomplete combustion of organic materials, and causes oxidative damage to cells and tissues due to reactive oxygen species (ROS). The purpose of this study is to investigate the inhibition of Tanshinone IIA and Baicalin on the formation of BaP as well as the cytotoxicity in human umbilical vein endothelial cells (HUVECs) induced by BaP. The results showed that BaP formations in mainstream smoke were inhibited by 21µg/cigarette of Tanshinone IIA with a 12.8% decrease, and by 60µg/cigarette of Baicalin with an 11.1% decrease, respectively. Tanshinone IIA could protect HUVECs from the damage caused by BaP in a dose-dependent manner from 7.5 to 30µg/ml. 6µg/ml Baicalin significantly increased the cell survival rate from 47.37% to 84.21% compared with BaP-treated cells. Both Tanshinone IIA and Baicalin markedly attenuated the increase of LDH release, enhanced the activity of SOD and GPx and inhibited the generation of MDA in BaP-damaged HUVECs in vitro. In vivo exploration showed that the two compounds were capable of enhancing the activity of SOD and inhibiting generation of MDA in mainstream smoke-damaged in mice. Superoxide anion radical and hydroxyl radical were obviously inhibited by Tanshinone IIA and Baicalin. These data demonstrate an inhibition of Tanshinone IIA and Baicalin on the formation of BaP and the cytotoxicity on HUVECs related to free Radical induced by BaP.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Benzo(a)pyrene Toxicity Diterpenes, Abietane Pharmacology Flavonoids Free Radical Scavengers Human Umbilical Vein Endothelial Cells Drug Effects Smoke Adverse Effects Smoking Animals Metabolism Cell Survival Cells, Cultured Chromatography, High Pressure Liquid Cytoprotection Dose-response Relationship, Drug Glutathione Peroxidase Pathology Humans Hydroxyl Radical Inhalation Exposure L-lactate Dehydrogenase Malondialdehyde Mice Mice, Inbred Icr Analysis Solid Phase Extraction Superoxide Dismutase Superoxides Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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