NDLI: ß-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

Please wait, while we are loading the content...

Year: 2017 Volume: 51

Year: 2017 Volume: 50

Year: 2017 Volume: 49

Year: 2016 Volume: 49

Year: 2016 Volume: 48

Year: 2016 Volume: 47

Year: 2016 Volume: 46

Year: 2016 Volume: 45

Year: 2016 Volume: 44

Year: 2016 Volume: 43

Year: 2016 Volume: 42

Year: 2016 Volume: 41

Year: 2015 Volume: 40

Year: 2015 Volume: 39

Year: 2014 Volume: 38

Year: 2014 Volume: 37

Year: 2013 Volume: 36

Year: 2013 Volume: 36 Issue: 3

Year: 2013 Volume: 36 Issue: 2

Downregulation of pro-inflammatory mediators by a water extract of Schisandra chinensis (Turcz.) Baill fruit in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.

Transcriptional regulation of glutathione biosynthesis genes, Î³-glutamyl-cysteine ligase and glutathione synthetase in response to cadmium and nonylphenol in Chironomus riparius.

Aroclor 1254 induced oxidative stress and mitochondria mediated apoptosis in adult rat sperm in vitro.

Does thyroid disruption contribute to the developmental neurotoxicity of chlorpyrifos?

Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model.

The effect of calorie restriction on acute ethanol-induced oxidative and nitrosative liver injury in rats.

ß-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

Combined treatment with verrucarin A and tumor necrosis factor- sensitizes apoptosis by overexpression of nuclear factor-kappaB-mediated Fas.

XRCC1 deficiency increased the DNA damage induced by Î³-ray in HepG2 cell: Involvement of DSB repair and cell cycle arrest.

Toxic effect of cooking oil fumes in primary fetal pulmonary type II-like epithelial cells.

Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1.

Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the Mediterranean gorgonian Eunicella singularis.

Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity.

Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system.

Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides.

Immune response to acetaldehyde-human serum albumin adduct among healthy subjects related to alcohol intake.

Effects of deltamethrin on biometric parameters and liver biomarkers in common carp (Cyprinus carpio L.).

Neurotoxicity of dibutyl phthalate in brain development following perinatal exposure: a study in rats.

Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.

Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice.

bFGF promotes the differentiation and effectiveness of human bone marrow mesenchymal stem cells in a rotenone model for Parkinson's disease.

Comparison of developmental toxicity of seven perfluoroalkyl acids to zebrafish embryos.

Study on osteogenesis promoted by low sound pressure level infrasound in vivo and some underlying mechanisms.

Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats.

Understanding the toxicity of carbon nanotubes in the environment is crucial to the control of nanomaterials in producing and processing and the assessment of health risk for human: a review.

Involvement of retinoic acid-induced peroxiredoxin 6 expression in recovery of noise-induced temporary hearing threshold shifts.

Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats.

Effects of selenium supplemented diets on growth and condition indexes in juvenile red swamp crayfish, Procambarus clarkii.

In vitro toxic action potential of anti tuberculosis drugs and their combinations.

T-2 toxin exposure induces apoptosis in rat ovarian granulosa cells through oxidative stress.

Carbonic anhydrase activity from the gilthead sea bream (Sparus aurata) liver: the toxicological effects of heavy metals.

Echocardiographic assessment of myocardial function in workers occupationally exposed to lead without clinically evident heart disease.

Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.

DNA damage and oxidative stress modulatory effects of glyphosate-based herbicide in freshwater fish, Channa punctatus.

Development of biomarker for detecting silver nanoparticles exposure using a GAL4 enhancer trap screening in Drosophila.

Gene expression profiling analysis of deoxynivalenol-induced inhibition of mouse thymic epithelial cell proliferation.

Health risk from As contaminated fish consumption by population living around River Chenab, Pakistan.

Characterization of phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: unique pyrene metabolism and species specificity observed in fish species.

The effect of air pollutants on the microecology of the respiratory tract of rats.

The association between blood pressure and blood cadmium in a Chinese population living in cadmium polluted area.

P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).

Activation of apoptotic pathway in normal, cancer ovarian cells by epothilone B.

Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on the aryl hydrocarbon receptor agonistic activity of hydroxylated polychlorinated biphenyls.

In vivo lung deposition and sub-acute inhalation toxicity studies of nano-sized alendronate sodium as an antidote for inhaled toxic substances in Sprague Dawley rats.

In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism.

Expedition of in vitro dissolution and in vivo pharmacokinetic profiling of sulfur nanoparticles based antimicrobials.

Neurotoxic effect of subacute benzo(a)pyrene exposure on gene and protein expression in Sprague-Dawley rats.

Interactive effect of oxytetracycline and lead on soil enzymatic activity and microbial biomass.

Diphlorethohydroxycarmalol attenuated cell damage against UVB radiation via enhancing antioxidant effects and absorbing UVB ray in human HaCaT keratinocytes.

Comparative study on effects of dietary with diphenyl diselenide on oxidative stress in carp (Cyprinus carpio) and silver catfish (Rhamdia sp.) exposed to herbicide clomazone.

Purification and characterization of antioxidant components from the fruiting bodies of Pleurotus abalonus including 9-beta-d-ribofuranosidoadenine, 5'-deoxy-5'-(methylthio)adenosine, and a triterpenoid.

Melittin: a lytic peptide with anticancer properties.

Effects of individual and binary-combined commercial insecticides endosulfan, temephos, malathion and pirimiphos-methyl on biomarker responses in earthworm Eisenia andrei.

ERK5 knock down aggravates detrimental effects of hypothermal stimulation on cardiomyocytes via Bim upregulation.

Cytotoxicity and the induction of the stress protein Hsp 70 in Chang liver cells in response to zearalenone-induced oxidative stress.

Year: 2013 Volume: 36 Issue: 1

Year: 2013 Volume: 35

Year: 2012 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2011 Volume: 31

Year: 2010 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

ß-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): the first step towards an experimental model for sporadic ALS.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	de Munck, Estefanía Muñoz-Sáez, Emma Miguel, Begoña G. Solas, M. Teresa Ojeda, Irene Martínez, Ana Gil, Carmen Arahuetes, Rosa Ma
Description	Country affiliation: Spain Author Affiliation: de Munck E ( Departamento de Biología Animal II, Universidad Complutense de Madrid, 28040 Madrid, Spain.)
Abstract	ß-N-methylamino-l-alanine (L-BMAA) is a neurotoxic amino acid that has been related to various neurodegenerative diseases. The aim of this work was to analyze the biotoxicity produced by L-BMAA in vivo in rats, trying to elucidate its physiopathological mechanisms and to search for analogies between the found effects and pathologies like Amyotrophic Lateral Sclerosis (ALS). Our data demonstrated that the neurotoxic effects in vivo were dosage-dependent. For evaluating the state of the animals, a neurological evaluation scale was developed as well as a set of functional tests. Ultrastructural cell analysis of spinal motoneurons has revealed alterations both in endoplasmic reticulum and mitochondria. Since GSK3ß could play a role in some neuropathological processes, we analyzed the alterations occurring in GSK3ß levels in L-BMAA treated rats, we have observed an increase in the active form of GSK3ß levels in lumbar spinal cord and motor cerebral cortex. On the other hand, (TAR)-DNA-binding protein 43 (TDP-43) increased in L-BMAA treated animals. Our results indicated that N-acetylaspartate (NAA) declined in animals treated with L-BMAA, and the ratio of N-acetylaspartate/choline (NAA/Cho), N-acetylaspartate/creatine (NAA/Cr) and N-acetylaspartate/choline+creatine (NAA/Cho+Cr) tended to decrease in lumbar spinal cord and motor cortex. This project offers some encouraging results that could help establishing the progress in the development of an animal model of sporadic ALS and L-BMAA could be a useful tool for this purpose.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Amino Acids, Diamino Amyotrophic Lateral Sclerosis Chemically Induced Motor Cortex Pathology Nerve Degeneration Spinal Cord Metabolism Physiopathology Animals Aspartic Acid Analogs & Derivatives Caspase 3 Choline Creatinine Dna-binding Proteins Disease Models, Animal Endoplasmic Reticulum Glycogen Synthase Kinase 3 Magnetic Resonance Spectroscopy Male Mitochondria Motor Activity Neurologic Examination Phenotype Rats Rats, Wistar Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in