NDLI: Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides.

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Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides.

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Effect of safeners on damage of human erythrocytes treated with chloroacetamide herbicides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bernasinska, Joanna Duchnowicz, Piotr Koter-Michalak, Maria Koceva-Chyla, Aneta
Description	Country affiliation: Poland Author Affiliation: Bernasinska J ( Department of Thermobiology, Institute of Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., 90-237 Lodz, Poland. joannab@biol.uni.lodz.pl)
Abstract	Chloroacetamides are used as pre-emergent substances for growth control of annual grasses and weeds. Since they can be harmful for crop plants, protective compounds (safeners) are used along with herbicides. So far, their effects on human blood cells have not been evaluated, and this study is the very first one devoted to this subject. We examined the harmful effects of chloroacetamides, their metabolites and safeners, used alone or in combination with herbicides, on human erythrocytes measuring the extent of hemolysis, lipid peroxidation and catalase activity. Higher impact of herbicides than their metabolites on all of the investigated parameters was found. Safeners alone did not produce any damage to erythrocytes and did not elicit any changes in oxidative stress parameters. Combination of safener with herbicide did not attenuate hemolysis of erythrocytes compared to the herbicide alone. Safeners reduced lipid peroxidation induced by herbicides, which suggest the role of safeners as antioxidants.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Acetamides Toxicity Erythrocytes Drug Effects Herbicides Protective Agents Pharmacology Antioxidants Catalase Blood Dose-response Relationship, Drug Metabolism Pathology Hemolysis Humans Lipid Peroxidation Oxidative Stress Pyrazoles Thiobarbituric Acid Reactive Substances Toluidines Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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