NDLI: Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation.

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Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation.

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Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sun, Xianwen Li, Qingyun Gong, Yi Ren, Lei Wan, Huanying Deng, Weiwu
Description	Author Affiliation: Sun X ( Department of Respiratory Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, PR China.)
Abstract	Patients with chronic obstructive pulmonary disease (COPD) respond poorly to corticosteroids. Histone deacetylase-2 (HDAC-2) plays a pivotal role in many cases of steroid insensitivity. The main aim of this study was to restore the smoking-induced reduction in corticosteroid sensitivity by increasing HDAC-2 activity using low-dose theophylline. Rats were exposed to cigarette smoke (CS) and treated with budesonide and two doses of theophylline. Besides the pathologic examination and cell counting in the bronchoalveolar lavage fluid (BALF), the expression of HDAC-2 and CXC chemokine ligand-8 (CXCL-8) were measured. Airway inflammation induced by CS was demonstrated by pathologic changes of lung tissue and increased level of CXCL-8. CS exposure also markedly decreased HDAC-2 expression. Moreover, a negative correlation was found between HDAC-2 activity and a lung destruction index. The index was restored to control levels with inhaled corticosteroid treatment in combination with a low, not a high, dose of theophylline. These results indicate that low-dose theophylline might provide protection from smoke damage and improve the anti-inflammatory effects of steroids by increasing HDAC-2 activity.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	7
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-07-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Adrenal Cortex Hormones Pharmacology Inflammation Chemically Induced Drug Therapy Smoke Inhalation Injury Adverse Effects Theophylline Animals Bronchoalveolar Lavage Fluid Budesonide Dose-response Relationship, Drug Histone Deacetylase 2 Metabolism Blood Interleukin-8 Lung Drug Effects Rats, Wistar Smoking Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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