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Development of biomarker for detecting silver nanoparticles exposure using a GAL4 enhancer trap screening in Drosophila.

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Development of biomarker for detecting silver nanoparticles exposure using a GAL4 enhancer trap screening in Drosophila.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tian, Hong Eom, Hyun-Jeong Moon, Sungjin Lee, Jeongmi Choi, Jinhee Chung, Yun Doo
Description	Author Affiliation: Tian H ( Department of Life Science, University of Seoul, Seoul 151-732, Republic of Korea.)
Abstract	Silver nanoparticles (AgNPs) have been widely used in commercial goods ranging from medical devices to home appliances. Their widespread application increase the risk related to their potential toxicity. Although several studies showed their acute hazardous effects on living animals, our understanding of chronic effects of AgNPs exposed by the environment we encounter in our everyday lives is still very limited. This is partly because of the lack of versatile animal model system for studying AgNPs effects on terrestrial animals including human. In this study, we used Drosophila model to study AgNPs toxicity in terrestrial animals, and found that long-term exposure of AgNPs, but not Ag ions, at low level (0.1 and 1µg/mL) significantly shortened the lifespan. By taking advantage of the power of Drosophila genetics, we also isolated a GAL4 enhancer trap line called M95, in which the expression of GAL4 is up-regulated in response to ingestion of AgNPs at concentrations as low as 0.1µg/mL. Interestingly M95 flies showed significantly increased tolerance to both AgNPs treatment and dry starvation probably due to up-regulation of JNK signaling. These findings suggest not only that M95 may be a very useful biomarker of AgNPs because of its high sensitivity and tolerance to AgNPs, but also that Drosophila may be a versatile terrestrial invertebrate model for studying the effects of AgNPs on human health.
File Format	HTM / HTML
ISSN	13826689
Issue Number	2
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Dna-binding Proteins Metabolism Drosophila Drug Effects Metal Nanoparticles Toxicity Saccharomyces Cerevisiae Proteins Silver Toxicity Tests Methods Transcription Factors Animals Animals, Genetically Modified Biological Markers Genetics Dose-response Relationship, Drug Genes, Reporter Jnk Mitogen-activated Protein Kinases Longevity Map Kinase Signaling System Starvation Transcription, Genetic Up-regulation Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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