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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jalaludeen, Abdulkadhar Mohamed Lee, Won Young Kim, Ji Hyuk Jeong, Ha Yeon Ki, Kwnag Seok Kwon, Eung Gi Song, Hyuk |
| Description | Author Affiliation: Jalaludeen AM ( Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea.); Lee WY ( Division of Food Bioscience, College of Biomedical and Health Science, Konkuk University, Chung-ju 380-701, Republic of Korea.); Kim JH ( Pourtry Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.); Jeong HY ( Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.); Ki KS ( Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.); Kwon EG ( Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.); Song H ( Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: songh@konkuk.ac.kr.) |
| Abstract | The present study was investigated the effects of biochanin A (BCA) on arsenic toxicity in rats. For this purpose, rats were orally treated with arsenic in the form of sodium meta-arsenite alone (10mg/kg body weight (bw)/day) and co-administered selenium (10mg/kgbw/day) and BCA at different doses (10, 20 and 40mg/kgbw/day) for 6 weeks. Arsenic altered the oxidative stress indices in both renal and cardiac tissues. There was an increase in plasma renal markers, triglyceride, lipoproteins with no alterations in cholesterol levels were noted in arsenic-intoxicated rats. Non-significant changes of phospholipids and free fatty acids levels in the tissues of arsenic-exposed rats. The biochemical disturbances were well correlated with the histological findings in the kidney, but not in the heart. The administration of BCA and selenium significantly reversed the alterations in the above-mentioned parameters in arsenic-intoxicated rats. Our findings revealed the beneficial effects of BCA against arsenic toxicity. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Arsenic Toxicity Biological Markers Analysis Genistein Administration & Dosage Heart Injuries Prevention & Control Kidney Diseases Animals Drug Administration Schedule Pharmacology Chemically Induced Metabolism Lipid Peroxidation Drug Effects Male Oxidative Stress Rats Selenium Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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