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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lu, Jing Fang, Baochen Ren, Mengrou Huang, Guoren Zhang, Shuang Wang, Yi Deng, Xuming Guan, Shuang |
| Description | Author Affiliation: Lu J ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China); Fang B ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.); Ren M ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.); Huang G ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.); Zhang S ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.); Wang Y ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.); Deng X ( Key Laboratory of Zoonosis Research Ministry of Education, Jilin University, Changchun, Jilin 130062, People's Republic of China. Electronic address: xumingdeng@jluhp.edu.cn.); Guan S ( Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China) |
| Abstract | 1,3-Dichloro-2-propanol (1,3-DCP) is a food born chloropropanol contaminant that has been detected during the production process of a wide range of foods. In this study, we investigated the effect of 1,3-DCP on lipid metabolism of mice after 13-week subchronic exposure. The data showed that 1,3-DCP (0.05-0.5mg/kg/day) could induce nonalcoholic fatty liver disease (NAFLD) in C57BL/6J mice and the NOAEL was 0.01mg/kg/day. In addition, we studied the signaling pathway to see how 1,3-DCP worked. The data showed that NAFLD induced by 1,3-DCP was due to the dysregulation of AMPK signaling pathway. As far as we are aware, this is the first study to use 13-week subchronic toxicology to investigate the effect of 1,3-DCP on the development of NAFLD in mice. Our study provided evidence for diet contaminants in the development of NAFLD and furthered the safety evaluation of 1,3-DCP through subchronic exposure. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Adenylate Kinase Metabolism Non-alcoholic Fatty Liver Disease Chemically Induced Alpha-chlorohydrin Analogs & Derivatives Administration, Oral Animals Lipid Metabolism Drug Effects Mice Mice, Inbred C57bl Enzymology Signal Transduction Toxicity Tests, Subchronic Administration & Dosage Toxicity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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