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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Manigandan, Krishnan Jayaraj, Richard L. Jagatheesh, Kaliaperumal Elangovan, Namasivayam |
| Description | Author Affiliation: Manigandan K ( Department of Biotechnology, School of Biosciences, Periyar University, Salem, 636011, Tamilnadu, India. Electronic address: biomani1@gmail.com.); Jayaraj RL ( Harborview Research & Training Building, University of Washington School of Medicine. Electronic address: richardljayaraj@gmail.com.); Jagatheesh K ( Department of Biotechnology, School of Biosciences, Periyar University, Salem, 636011, Tamilnadu, India. Electronic address: kjagatheesh@gmail.com.); Elangovan N ( Department of Biotechnology, School of Biosciences, Periyar University, Salem, 636011, Tamilnadu, India. Electronic address: elangovannn@gmail.com.) |
| Abstract | Taxifolin (TAX) is a natural source of bioflavonoid found in various conifers. In this study, initially we investigated the antioxidant potential of TAX under in vitro assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric-ion reducing power (FRAP) and hydroxyl radical (OH). The activities of DPPH, ABTS, FRAP and OH radical levels were significantly inhibited by TAX with an IC50 values of 16.48, 66.34, 18.17 and 11.42µg/ml, respectively. Secondly, TAX exhibited a strong protection against OH mediated DNA damage on pUC19 plasmid DNA at 1.0µg/ml. Finally, we evaluated the protective mechanism of TAX against cadmium intoxicated zebrafish embryos (Danio rerio). We found that embryos exposed to 100µM Cd exhibited significantly reduced survival, delayed hatching and phenotypic abnormalities at 24, 48, 72 and 96hours post fertilization (hpf). Similarly, Cd intoxicated embryos showed significantly increased cardiac function (131beats/min) at 60hpf. Conversely, treatment with TAX (0.1, 1.0 and 10µM) significantly enhanced the antioxidant enzyme levels (SOD, CAT, GPx and GR) by reducing the lipid peroxidation (MDA) in zebrafish embryos. Collectively, our results concluded that TAX could act as a potent redox scavenger against oxidative DNA damage and also functions as a crucial suppressor of Cd toxicity in zebrafish embryos. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antioxidants Administration & Dosage Cadmium Toxicity Embryo, Nonmammalian Drug Effects Quercetin Analogs & Derivatives Zebrafish Embryology Animals Pharmacology Dna Damage Dose-response Relationship, Drug Embryonic Development Gene Expression Regulation, Developmental Lipid Peroxidation Oxidative Stress Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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