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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bas, Hatice Kalender, Yusuf Pandir, Dilek Kalender, Suna |
| Description | Author Affiliation: Bas H ( Bozok University, Faculty of Arts and Science, Department of Biology, 66100 Yozgat, Turkey. Electronic address: htc.haticebas@gmail.com.); Kalender Y ( Gazi University, Faculty of Science, Department of Biology, 06500 Ankara, Turkey.); Pandir D ( Bozok University, Faculty of Arts and Science, Department of Biology, 66100 Yozgat, Turkey.); Kalender S ( Gazi University, Gazi Education Faculty, Department of Science Education, 06500, Ankara, Turkey.) |
| Abstract | The adverse effects of lead nitrate (LN) and the preventive role of sodium selenite were investigated in diabetic and non-diabetic rat blood by measuring trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP), malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) also by evaluating DNA damage with comet assay. LN increased the levels of MDA, tail DNA%, mean tail length and tail moment, decreased the enzymes activities, FRAP and TEAC values. In sodium selenite+LN group, we observed the protective effect of sodium selenite on examining parameters. Diabetes caused alterations on these parameters, too. We found that sodium selenite did not protect against diabetes caused damages. As a result, LN caused toxic effects on blood cells and sodium selenite alleviated this toxicity but it did not show preventive effect against diabetes. Also, LN caused more harmfull effects in diabetic groups than non-diabetic groups. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Dna Damage Drug Effects Diabetes Mellitus, Experimental Blood Lead Adverse Effects Nitrates Oxidative Stress Sodium Selenite Administration & Dosage Animals Catalase Enzymology Erythrocytes Gene Expression Regulation, Enzymologic Glutathione Peroxidase Glutathione Transferase Leukocytes Malondialdehyde Rats Pharmacology Superoxide Dismutase Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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