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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bahadar, Haji Maqbool, Faheem Mostafalou, Sara Baeeri, Maryam Rahimifard, Mahban Navaei-Nigjeh, Mona Abdollahi, Mohammad |
| Description | Country affiliation: Iran Author Affiliation: Bahadar H ( Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran.); Maqbool F ( Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran.); Mostafalou S ( School of Pharmacy, Ardebil University of Medical Sciences, Ardebil, Iran.); Baeeri M ( Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran.); Rahimifard M ( Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.); Navaei-Nigjeh M ( Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.); Abdollahi M ( Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, International Campus, Tehran, Iran) |
| Abstract | Benzene (C6H6) is an organic compound used in petrochemicals and numerous other industries. It is abundantly released to our environment as a chemical pollutant causing widespread human exposure. This study mainly focused on benzene induced toxicity on rat pancreatic islets with respect to oxidative damage, insulin secretion and glucokinase (GK) activity. Benzene was dissolved in corn oil and administered orally at doses 200, 400 and 800mg/kg/day, for 4 weeks. In rats, benzene significantly raised the concentration of plasma insulin. Also the effect of benzene on the release of glucose-induced insulin was pronounced in isolated islets. Benzene caused oxidative DNA damage and lipid peroxidation, and also reduced the cell viability and total thiols groups, in the islets of exposed rats. In conclusion, the current study revealed that pancreatic glucose metabolism is susceptible to benzene toxicity and the resultant oxidative stress could lead to functional abnormalities in the pancreas. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzene Toxicity Insulin Blood Islets Of Langerhans Drug Effects Oxidative Stress Animals Administration & Dosage Blood Glucose Metabolism Cell Survival Dna Damage Glucokinase Enzymology Lipid Peroxidation Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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