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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abdel-Bakky, M. S. Helal, G. K. El-Sayed, E. M. Saad, A. S. |
| Description | Country affiliation: Saudi Arabia Author Affiliation: Abdel-Bakky MS ( Faculty of pharmacy, Al-Azhar university, Cairo 11884 Egypt); Helal GK ( Faculty of pharmacy, Al-Azhar university, Cairo 11884 Egypt); El-Sayed EM ( Faculty of pharmacy, Al-Azhar university, Cairo 11884 Egypt.); Saad AS ( Faculty of Pharmacy, Delta University for Science and Technology, Mansoura, Egypt. Electronic address: mosa1200@yahoo.com.) |
| Abstract | Tissue factor (TF) is a membranous glycoprotein that activates the coagulation system when blood vessels or tissues are damaged. TF was up-regulated in monocrotaline (MCT)/lipopolysaccharide (LPS) hepatotoxicity model. The present study aimed to test the hypothesis that TF-dependent fibrin deposition occurs in liver toxicity induced by CCl4 in mice. Pericentral deposition of TF and fibrin is induced after CCl4-induced liver toxicity. The toxicity was evaluated by determination of serum activities of ALT, AST and ALP as well as GSH content and histopathological changes. The results showed that injection of mice with TF-antisense deoxyoligonucleotide (TF-AS) prevented the accumulation of TF and fibrin in the hepatic tissues. Furthermore, it significantly restored blood biochemical parameters, GSH content and distorted histopathological features caused by CCl4. The current study demonstrates that TF activation is associated with CCl4-induced liver injury. Furthermore, administration of TF-AS successfully prevented this type of liver injury. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Carbon Tetrachloride Toxicity Drug-induced Liver Injury Pathology Fibrin Metabolism Thromboplastin Animals Etiology Dna, Antisense Administration & Dosage Pharmacology Disease Models, Animal Gene Expression Regulation, Enzymologic Drug Effects Glutathione Male Mice Antagonists & Inhibitors Transaminases Blood Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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