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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Djeffal, Assia Messarah, Mahfoud Boumendjel, Amel Kadeche, Lilia Feki, Abdelfattah El |
| Description | Country affiliation: Algeria Author Affiliation: Djeffal A ( Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria Applied Biochemistry and Microbiology Laboratory, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria.); Messarah M ( Animal Ecophysiology Laboratory, Faculty of Sciences, Sfax, Soukra road, Tunisia mahfoud.messarah@univ-annaba.org mmessarahdz@yahoo.fr.); Boumendjel A ( Laboratory of Biochemistry and Environmental Toxicology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria.); Kadeche L ( Animal Ecophysiology Laboratory, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria.); Feki AE ( Animal Ecophysiology Laboratory, Faculty of Sciences, Sfax, Soukra road, Tunisia.) |
| Abstract | Methomyl (MET) is used worldwide in agriculture and health programs. Besides its advantages in the agriculture, it causes several toxic effects. The objective of this study was to examine the potential ability of vitamin C and/or selenium (Se), to alleviate the oxidative damage parameters, against MET-induced changes in blood biochemical markers and oxidative damage in liver and kidney of male Wistar rats. The animals were randomized into five groups of eight each: group I served as control rats; group II received MET (8 mg/kg body weight (BW)) in drinking water; group III received both MET and vitamin C (200 mg/kg BW; by intraperitoneal injection); group IV received both MET and Se (0.6 mg/100 g BW). Animals of group V were treated with MET, vitamin C and Se. A significant increase in the levels of hepatic markers enzymes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase) was determined. Furthermore, renal markers such as urea and creatinine were increased in MET-treated rats. Additionally, serum cholesterol and triglycerides were significantly enhanced. Exposure of rats to MET caused significant increase in malondialdehyde levels, thus causing a drastic alteration in antioxidant defense system, particularly in the activities of catalase and glutathione-S-transferase and glutathione peroxidase. However, simultaneous supplementation with vitamin C and Se restored these parameters partially. In conclusion, the results of the current study revealed that MET-induced toxicity caused perturbations of some biochemical parameters, lipid peroxidation and alterations in the antioxidant enzymes in liver and kidney homogenates. Administration of vitamin C and Se exhibited protective effect by inhibiting MET-induced toxicity in liver and kidney. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 1 |
| Volume Number | 31 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Antioxidants Pharmacology Ascorbic Acid Methomyl Toxicity Oxidative Stress Drug Effects Selenium Animals Body Weight Glutathione Analysis Kidney Pathology Lipid Peroxidation Liver Male Organ Size Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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