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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brkic, Dragica Szakonyne-Pasics, Ilona Gasic, Slavica Teodorovic, Ivana Raskovic, Bozidar Brkic, Nenad Neskovic, Nesko |
| Description | Author Affiliation: Brkic D ( Institute of Pesticides and Environmental Protection, Banatska 31-b, 11080 Belgrade-Zemun, Serbia. Electronic address: dragica.brkic@pesting.org.rs.); Szakonyne-Pasics I ( Toxi-Coop, Toxicological Research Center Zrt., Pálya u. 2, H-2120 Dunakeszi, Hungary. Electronic address: ilona.pasics@toxicoop.hu.); Gasic S ( Institute of Pesticides and Environmental Protection, Banatska 31-b, 11080 Belgrade-Zemun, Serbia. Electronic address: slavica.gasic@pesting.org.rs.); Teodorovic I ( University of Novi Sad, Faculty of Sciences, Trg Dositeja Obradovica 2, 21000 Novi Sad, Serbia. Electronic address: ivana.teodorovic@dbe.uns.ac.rs.); Raskovic B ( University of Belgrade, Faculty of Agriculture, Nemanjina 6, 11080 Belgrade-Zemun, Serbia. Electronic address: raskovic@agrif.bg.ac.rs.); Brkic N ( Ministry of Agriculture and Environmental Protection, Directorate for Water, Bulevar umetnosti 2a, 11070 Belgrade, Serbia. Electronic address: nbrkich@gmail.com.); Neskovic N ( Institute of Pesticides and Environmental Protection, Banatska 31-b, 11080 Belgrade-Zemun, Serbia. Electronic address: nneskovic@beotel.net.) |
| Abstract | Subacute and subchronic toxicity of the herbicide Avalon(®), a mixture of bentazone and dicamba, were tested on rats. Avalon(®) was administered at dose levels of 250, 500 and 1000mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzothiadiazines Toxicity Dicamba Gene Expression Regulation, Enzymologic Drug Effects Herbicides Toxicity Tests, Subacute Methods Toxicity Tests, Subchronic Alanine Transaminase Metabolism Alkaline Phosphatase Animals Aspartate Aminotransferases Administration & Dosage Dose-response Relationship, Drug Drug Combinations Female Male Rats Sex Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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