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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liu, Shan Zhang, Xiao-Ping Han, Na-Na Lv, Shen Xiong, Jun-Yu |
| Description | Country affiliation: China Author Affiliation: Liu S ( Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, China.); Zhang XP ( Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, China.); Han NN ( Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, China.); Lv S ( Laboratory of Molecular Biology, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, China.); Xiong JY ( Department of Anesthesiology, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116027, China. Electronic address: jyxiong0639@163.com.) |
| Abstract | Etomidate is frequently used as an anesthetic and sedation agent in the clinic setting. This study determined that a low-dose pre-infusion followed by a continuous dose infusion of etomidate could reduce etomidate-induced adrenal gland insufficiency. Sixty adult male Wistar rats were used, with six rats per group. Based on preliminary experiments, 0.6mg/kg etomidate was selected as the low dose for this study. Oxidative stress and apoptosis-related proteins in the adrenal glands were assayed using Western blot, and serum levels of CORT and 11ß-hydroxylase were detected using ELISA. Pretreatment with a single bolus of low dose etomidate significantly increased the levels of CORT and 11ß-hydroxylase as well as the activities of superoxide dismutase (SOD), catalase (CAT) and glutathioneperoxidase (GPx) in the adrenal glands, but reduced nitric oxide (NO) production when compared to the positive group. Furthermore, Western blot data showed that pretreatment with low dose etomidate increased extracellular signal-regulated kinase1/2 (ERK1/2), CREB and bcl-2 activation, but suppressed the p-p38, c-JunN-terminal kinase (JNK), inducible NO synthase (iNOS), cleaved-caspase3, cleaved-poly-ADP-ribose polymerase (PARP), bax, and AKT activation. The ERK inhibitor PD98059 and the p38MAPK inhibitor SB203580 abolished the protective effect of low dose etomidate pretreatment. These data demonstrated that pretreatment with low dose etomidate attenuated etomidate-induced adrenal insufficiency to rat adrenal glands. Oxidative stress-related MAPKs and apoptosis proteins might be responsible for mediating the etomidate preconditioning effect in rats. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Adrenal Insufficiency Prevention & Control Etomidate Administration & Dosage Adverse Effects Mitogen-activated Protein Kinases Metabolism Oxidative Stress Drug Effects Chemically Induced Enzymology Animals Apoptosis Dose-response Relationship, Drug Pharmacology Gene Expression Regulation, Enzymologic Infusions, Intravenous Male Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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