NDLI: The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage.

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The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage.

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The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Jiaqin Song, Meiyan Li, Yansen Zhang, Yonghui Taya, Kazuyoshi Li, ChunMei
Description	Author Affiliation: Chen J ( College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.); Song M ( College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.); Li Y ( College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.); Zhang Y ( College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China.); Taya K ( Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.); Li C ( College of Animal Science and Technology, Nanjing Agricultural University, 1 Weigang, Nanjing 210095, PR China. Electronic address: chunmeili@njau.edu.cn.)
Abstract	We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for 28 days. The control group received a basal diet and was injected with vehicle alone. Treatment with PS prevented the elevation of the total bilirubin levels, as well as an increase in serum alkaline transaminase and aspartate transaminase, which are typically caused by PNP-induced liver damage. Histopathologically showed that liver damage was significantly mitigated by PS treatment. However, there was no significant change in antioxidant enzyme activities, and the Nrf2-antioxidant system was not activated after treatment with PS. These results suggest that PS could mitigate liver damage induced by PNP, but does not enhance antioxidant capacity.
File Format	HTM / HTML
ISSN	13826689
Volume Number	41
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2016-01-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Drug-induced Liver Injury Prevention & Control Nitrophenols Toxicity Phytosterols Administration & Dosage Transaminases Blood Animals Bilirubin Metabolism Pathology Gene Expression Regulation, Enzymologic Drug Effects Injections, Subcutaneous Male Nf-e2-related Factor 2 Pharmacology Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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